I am 44 year old male with fasciculations that began subtly in my right calf 15 months ago. They have since progressed to constant in my R calf and foot, + sporatic everywhere else on my body. Two negative EMG's (last one 10 months ago), neg MRI C-spine, L-spine, & brain. Extensive lab work all neg. No gross weakness, but "subjective' weakness on & off in all four limbs (not all at the same time). I also get tremorous when exerting any muscle. ie: my arm visibly shakes when picking up something substantial. This affects all my muscles & started around the same time as my fasciculations. The past several months, noticed some loss of muscle mass medial distal L thigh & medial R forearm. No injury or other reasons known to explain these findings. Two neurologist (one is an "expert" in the field) say they don't think it is ALS, since I don't have any real weakness. They can't explain the atrophy or the shaking, but tell me not to worry. I am still worried as things seem to keep slowly progressing. I feel like I've worn out my welcome at the physician's office. Am I a hypochondriac? I seem to be obsessed with my condition (not just my own opinion). I would really appreciate your opinion and advise! Are there other conditions that my cause these symptoms?
I've tried magnesium & quinine without relief of fasciculations. Quinine has caused tinnitus & hearing loss.
Any other suggestions?
Thank you for your response.