B6 (pyridoxal phosphate) levels very high in bloodwork

[ballagher]

I have been tested twice recently for B6 level.  My first test two months ago indicated a 156 level with normal range being 20-96.  My second test indicated at 283 level.  My physician has no idea what this means and if there is a problem.  I am concerned that there is a toxic level of B6 and I should be doing something about it.  I'm not talking anything except multi-vitamin.  I've been concerned about my health for some time as I'm quite fatigued, anxious at work, balance issues (the term lightheaded would be the closest) eyes are sensitive to light, have trouble focusing on people when they talk, and have a few other issues like trouble concentrating, sense of smell has been gone for years and my sense of taste has been affected for quite some time as well.  My skin is quite raw on the knuckles and I think I have psoriasis as well as my nails are pitted and raised.  Not sure what is related but I definitely feel that there is something physicially wrong with me and this high B6 level has been the first thing to come up as being something worth pursuing.  Any help would be appreciated.  

[cindy777798]

check out Tylenol has B6 (Pyridoxin) in it.

[Cohochick]

Thank you!! To all of you thank you! I feel like I have somebody who can sympathize/relate how I feel now. My B6 was over 175 and I hadn't taken supplements in over a year. My neurologist said that was the only thing wrong with the 17 tubes of blood they pulled and ran. I have had debilitating neuropathy, crawling skin, numb spots, muscle pain, fatigue, tremors, insomnia, spots in my brain on the MRI with no diagnosis, I can go on and on but it sounds like you all know how I feel. I have had these symptoms that have been increasing for over a year with a remarkable increased of pain in the past month. My doc was very surprised that I hadn't taken any multi vites in a long time and suggested that I start at my age completely dismissing my b6 levels as a fluke. I took his education to heart and started taking a Pre Nat vit about 1 month ago. I sit and read all of what you are talking about and can kick myself for starting a multi vit and recognize that my upslope in symptoms coincide with the start of the supplement.
I'm going to look into what foods carry a high level of b6 and see if staying away from it helps my symptoms subside.
Talking with my fiancé he was wondering why I was so upset to not have a diagnosis. My reply is if I have a diagnosis at least I can find a support group of others who are suffering in the same manner. I know now that there are others out there who are suffering the same as me, I feel like I have a home.
Thank you.

[Liza2483]

I just got my blood work and I too was told that my B6 and b 112 is high.  this is my first time.  I was just diagnose with fibromyalgia.  I have pain all over sometimes it is my back or my hands, or my shoulders or any part of my body.  I am embarrassed to asked for prayers because I am always in pain.  I was  finally told I have fibromyalgia. and now is in the process of fixing my medication.  my latest problems is constipation and bloating.  Help me is you have any insight or solution please.

[juliana508]

Hi everyone,

I have just fallen across this page.  I have most of the symptoms mentioned and have been diagnosed with HYPOPHOSPHATASIA. It is classified as a metabolic bone disease and is ultra rare, few doctors have heard of it.  Do not confuse this with hypophosphatemia that is completely different medical problem.  HYPOPHOSPHATASIA is a genetic condition whereby a bit of gene number one is missing which means you cannot make enough of the enzyme ALKALINE PHOSPHATASE, or that which you have is not functional as I understand it.  This is easy to check.  Lack of alkaline phosphatase explains the high B6 as B6 is PYRIDOXIL 5 PHOSPHATE.  Without the enzyme you cannot metabolise phosphates in the body, therefore the B6 is not processed, you may even have symptoms of deficiency.  I too have leaky gut, IBS, allergies, muscle weakness etc etc!  Usually people present with bone fractures, typically metatarsal fractures of the feet are affected & of the femur.

Let me know what you  think, best wishes,
Juliana

[Harp1234]

What was your treatment?   My doctor is wondering if I have this.

[lstk8888]

Hi Everyone,
I just found this site and I have been reading the older posts. I don't have the time right now to continue reading. I have had two blood tests with very elevated B6 levels, in the 300 range when normal was up to 90. I have digestive issues, looked at wiki and it said where the B6 is absorbed in the digestive tract. I'm wondering if I'm not absorbing it and it's staying in my blood stream causing trouble. I have leaky gut, and irritable bowel. Have had trouble with my digestion for a long time. I wanted to post this about digestive issues, wondering if anyone else has had that in combination with the elevated B6. Have to go but I will come back and post more about my past symptoms in the next few days.
Laura K

[walkerwl]

I know this is quite old but did you ever figure out what was causing the high b6?

[ballagher]

I had similar ranges in past and stomach issues (hiatal hernia requiring reflux meds). Would like to explore that more.

[xDUSKx]

Hello,
In September of 2012, I went to the Hospital because of muscle weakness, muscle twitching, and muscle wasting. Later in May of 2013, I was diagnosed with ALS. But, I am unusually young to have ALS and I think something's not right.
My point is... all of my test results (about 85) were perfect except for two.
Vitamin B6 Level was 384 (normal range 20 - 125)
Vitamin B12 Level was 1,850 (normal range 180 - 914)
The doctors had no explanation for the extremely high levels.
I rarely eat meats and I don't take B supplements.
So I was wondering, Is my "ALS" really a B problem?
Has this happened to anyone else?

[Lymeartist]

Get a Lyme test and MAKE SURE YOU SEE THE ACTUALS RESULTS WITH HIGHLIGHTED REATIVE BANDS.   A Dr will tell you, "you are negative" if you don't have at least 5 bands.  What they don't tell you is that those bands are also indicative of co-infections from Lyme.  The test is also over 30 yo and it only tests for one of the Lyme spirochete and there are at least 5 more found since then.  Then go to a Lyme literate MD found on ILADS.org