Have had following symptoms,increasing frequency since 11/05. Background:50F.5/05 Resection meningioma right parietal. 09/05 diagnosed Hashimotos Hypothyroid. Synthroid.137 TSH 1.87 FT4 1.40.10/07 neuro diagnosed RLS. Besides known rls symptoms had/have morning symptoms. Awakened early AM startled, stressed,wired/ tired,sense of dread,shaky,jumping out of skin,adrenaline rush. Difficult to describe, determined not panic attacks. Somewhat relieved getting up to move around. Before was told RLS internist called this a Restless Syndrome. Had very low ferritin/iron at the time.Took iron pills,values went up, symptoms did not abate. 8/07 Had intensive work up with endocrinologist, sent by GYN. Cortisol, catecholamines, other adrenal tests.Only noticeable result low Dopamine. This result met with little concern. After diagnosis RLS 10/07 started Requip. Worked like magic from first .Actual RLS symptoms abated, bad wakings CEASED. Was at 2 mg nightly. End 1/08 small weight gain, minor edema. Short of breath. Suddenly symptoms increased.Gained more than 25 lbs in 10 weeks.Feet/ ankles/ fingers/abdomen terribly swollen. All sorts of tests including kidney,liver,congestive heart failure. No answers. Back to neuro. He determined this to be "rare" side effects from Requip. Took me off straightaway. I hated that because it worked so well. This as of April 28th. Was started on Sinemet. Was told this does not work as well as Requip, but was less likely to have same side effects. Said he could add darvocet if necesary.Also take ativan 1mg 3 x daily since brain surgery, and 1-2 at night for help with sleep. Every other sleep aid made morning "miseries"symptoms worse. Tapered Requip withdrawal while adding Sinemet. Right now taking 1/2 afternoon and 1 at night. Previous side effects have abated somewhat. But offers little help with night RLS. NO help with bad waking. Horrible to go back to where I was after those months of peaceful nights and NORMAL waking. Any help welcome.