Many thanks for replies. Update on mum. She stopped Letrozole after 6 weeks as no response. Her CA is now 4800 after having had approx. 4 mths or 5 off chemo. Her scan says prog. dis at mulitple sites. Sais liver serosa fulciform ligament is 31mm from 22mm. surface of segment 7 also. Splenic hilum 16mm focus. Increased omental disease. Small vol ascites in pelvis.Focus of disease anterior to pancreatic head increased to 42mm from 9mm. Pls can you explain this report and how you see this. Is it all doom, She has started taxol for 18 weeks course. Her lymph legs are bigger. She is always very tired and has pain in lower left under breast bone area. Is that the liver. Does this sound like it is progressing to her liver or pancreas. Her shortness of breath is extreme. Many thanks