I have, over the last approximately 15-20 years suffered from swelling of the back of the tongue and the throat, and of the sinus cavities, perpetual unproductive cough, continual sinus drainage down the back of the throat and sometimes to the front of the nose, and overall fatigue and depression as a result. It has gotten so bad that I have had to give up the running and sports in which I used to participate. It is a hindrance to my overall quality of life. I have had several courses of immunotherapy over my life, beginning as a child, and currently. I last suffered asthma when I was 12. I have since taken several spirometry tests and a methacholine challenge test which all proved negative. I have had a bronchoscopy taken which showed nothing, but also had a nasal endoscopy resulting in decision to perform septoplasty. This relieved the stuffy noses I was having, but drainage and cough have worsened. (NOTE: I question whether this is a cause of my increased coughing problems.) Other tests taken have been upper gastrointestinal tract endoscopy (negative), thyroid function tests (showed normal), nasal endoscopy (showed no changes since septoplasty), erythrocyte sedimentation rate (showed normal), and laryngoscopy of vocal cords (showed normal; however it found thickened and boggy nasal turbinates), blood gas test (showed normal). Have found LARGE doses of prednisone help greatly (methylprednisolone, less so), but also cause side effects. Am currently taking Astelin and Rynatan as a steady regimen and Flonase semi-regularly. I am at my wit's end....any other ideas?