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2nd HSV2 Test Results...next step?

Dr. Handsfield,

I am following up on a posting of mine to which you responded and I found quite helpful. To summarize my situation - HerpesSelect test results: HSV1 Negative, HSV2 Positive 2.04. No history of lesions or noticeable symptoms of infection. I located a dermatologist that performs the Biokit pocket test. The test results were negative which was a relief. However, I don't want to count any chickens before they are hatched. Do you recommend any further confirmatory testing? If so what kind? I am anxious to put this stressful ordeal behind me but want to make sure I am doing it the right way. Your thoughts are appreciated.


My original post:
http://www.medhelp.org/posts/show/559512?camp=27
3 Responses
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239123 tn?1267647614
MEDICAL PROFESSIONAL
Regardless of HSV-1 results, around half of HSV-2 results with ELISA ratios around 2.0 are false positive.  The available data suggest that Biokit is an effective tie breaker.  However, WB is the ultimate gold standard to resolve possible false positive results.  I see no need for it, but it's fine with me if you want to have it done.  It's your money.

No more discussion please, and no more new threads on the topic.  Thanks.
Helpful - 0
Avatar universal
Wow, really? I have been leary of relaxing because I came across an older post (from 2006) in which you said:

"Most false positives occur in people with positive HSV-1 results.  In people without HSV-1, any HSV-2 result above 1.1 is true positive."

Maybe I'm paranoid about the Biokit results, but if you could indulge me one last followup - why is a tie breaker (Western Blot or another IGG test) not recomended in this case? Could an ealry infection yield the differing results?

Thank you again.
Helpful - 0
239123 tn?1267647614
MEDICAL PROFESSIONAL
Start counting those chickens.  As best we know from the most up-to-date research, you can rely on the negative Biokit resultt.  You don't have HSV-2.

Regards--  HHH, MD
Helpful - 0

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