Fatigue
Weakness
Weight gain or increased difficulty losing weight
Coarse, dry hair
Dry, rough pale skin
Hair loss
Cold intolerance (can't tolerate the cold like those around you)
Muscle cramps and frequent muscle aches
Constipation
Depression
Irritability
Memory loss
Abnormal menstrual cycles
Decreased libido (sex drive)
Sounds more like hyperthyroidism to me. You may be getting too much of a dose of the unithroid.
it could be -- would confirm that you were hypothyroid (ie, high TSH) and then consider cutting the unithroid in half for 7-14 days then resuming a whole tablet. Anxiety can be a symptom of both hypo and hyper.
The nodules need to be evaluated -- if >1cm, FNA biopsy.