Can someone help me figure this all out?

[guppy79]

I am 38 years old and had my spleen removed 18 years ago and immediately developed portal vein thrombosis and have been on coumadin ever since. For the past 7-8 years I have had an elevated WBC between 12-18K (lymphs 4.6, mono 1.6, and and EOS 0.6) in February. Then this December during a upper endoscopy I was told that I have duodenal intraepithelial lymphocytosis with normal villous architecture.

Blood work performed showed, that I don't have celiac disease and no signs of lupus or other autoimmune type disease.  My GI says it could be caused by "any medication" after I told him it could not be caused by NSAIDs due to the coumadin. My hematologist says it was caused by my splenectomy. Does anyone else think this could all be related? Thank you.  

[SassyLassie]

Hello~Removing your spleen is a major surgery and leaves you with a compromised immune system. For these reasons, it's only performed when truly necessary.  So, I would imagine that the high WBC could be due to the body fighting off some type of infection. In answer to your question then, yes, it could all be related.