Hi
Welcome to the MedHelp forum!
Usually conditions of heart, kidney, liver or low protein or severe anemia, which cause ankle and feet swelling, cause both ankles and feet to swell. Hence you will need to get heart function assessed by ECHO and EKG, get kidney and liver function tests done and get a complete blood picture for anemia. Low sodium in blood, hypothyroidism and malabsorption syndromes causing low protein in blood have to be looked into.
Some of it has been investigated. Liver and kidney function needs to be assessed through blood tests. It can even be infection of the lymphatics.
Please discuss with your husband’s treating doctor. Hope he gets well soon!
Take care!
has he gotten any blood work down for other possibilities (i.e diabetes etc)?
I would think something along the lines of a thyroid problem (hyperthyroidism or hypothyroidism). The question after that, however, becomes: "Why are the thyroids acting weird?". Since there was also spleen involvement, it is possible that that this could be due to a chronic infection of some type - but could also be due to pancreatic function impairment. But, really, first step I would take is to ask the doctor to assess his thyroid function; after that, additional things can be brought up or ruled out.