You can get a rash and painful skin swelling on your hands and feet so I would talk to doc about this. I would cut back to 450 and see if it goes away, however there is a chance of withdrawal issues, so taper carefully and talk to a pharmacist or doc for info about tapering.
You need to see your psychiatrist. You're on a very high dose of Effexor, and now you're also on a low dose of another med that targets serotonin. Two things might be happening -- one is an overdose of serotonin. The second is an overdose of dopamine. Effexor doesn't target dopamine directly, but when you get into high doses of it the balance between your various brain neurotransmitters get thrown off and you can suffer the effects you might suffer from drugs that more directly affect dopamine. Too much of it can cause symptoms similar to what Parkinson's sufferers get, though it isn't that disease, just symptoms like what you get with it. That's why I encourage you to talk this over with your psychiatrist, as you might not be able to tolerate such a high dose of the Effexor or the combination or both.
Thank you very much for taking the time to respond on this one guys.
I was checked for diavetes but was negative.