Endep is an anti-depressant and I am a bit surprised that you are taking it for “severe allergies and angioedema." You are correct in assuming that at least some of your symptoms may be side effects of this drug. There are other, newer anti-depression drugs with fewer side effects and your doctor would be familiar with these. And there are more effective drugs for the treatment of allergies and angioedema.
The best advice I can give is that you speak with your doctor: First to clarify the reason(s) for taking this drug. If, for depression, there are other drugs that would work as well or better, with fewer side effects. Second, to ask that he/she reevaluate the diagnosis of angioedema. If that diagnosis is correct consideration should then be given to the treatment with a more effective drug specific for that condition.
Good luck
Thank you for your comment. From your comment I am wondering what sort of Doctor you are. My allergist prescribed endep. He would prescribe me a small dose and after a week ask if my facial swelling was any better. I would say no and he would increase my dosage to the point where he wanted me to take a daily dose of 150mg which is ridiculous so I never went there again. Also before this he had me on durectics ( though it was excess fluid) which made my heart race. I now go to another allergist who said I had ' text book' angioedma facial swelling and stated that I was On the right tablets. I also found a GP with experience in agioedema who also stated that the endep in my case was not for depression and whenever I have to go to another doctor they don't listen to me and they tell me I must be depressed cause I am taking endep ( more stupid ignorance) So thanks for stating the obvious. Oh I also take an antihistamine and zantax and I my allergies still affect me. Thanks again