Hi. It would really be difficult for anyone in this forum to tell you what that spot is, since we have not seen and examined it closely. Chemotherapy can cause darkening of discrete areas of the skin, and this could be one possible explanation. That spot may also be a bruise. Chemotherapy can lower platelet counts and make skin capillaries more fragile, which could lead to bruises. A consult with a dermatologist will certainly help, if your friend's primary physician is at a loss on what's causing that spot.