Medication isn't working properly?

[Rayray9889]

I have been on a 300 mg dose of Bupropion XL for about a half year now. I also am on a 100 dose of Zoloft. I was originally on only Zoloft but it wasn't working well so I got put on Bupropion XL which worked. I take Trazidone when needed for my sleeping issues. I never had any side affects from it until recently. I've noticed that in the past month I would get nausea after I take Bupropion, as well as feeling jittery and tense. I can't relax and I feel like I'm consistently paranoid. I'm not sure what I should do. I'm at college away from home where my therapist and psychiatrist are. I don't want to get another as rehashing what I went through is something that I don't want to do and I can't see my psychiatrist until March. Any advice on what I should do?

[Paxiled]

Well, sometimes it's not a bad idea to get a new look on things by seeing a different psychiatrist.  I don't know how far into your education you are, but if it's early in your college stay you're going to need help from time to time.  If you're adamant about not seeing another shrink, try setting up a telephone appointment with you doc at home.  There could be several things happening.  It could be the drugs just aren't working as well anymore.  It could be your psychiatrist has you on three different meds that affect serotonin to some degree, which can be dangerous and would need pretty regular monitoring.  It's hard to understand why you weren't tapered off Zoloft before going on wellbutrin if the Zoloft wasn't working -- when you augment, or add another drug to what you're taking, it's because the drug you were taking is working but not quite well enough so you add another.  If it's not working well there's really no reason to augment it -- you stop taking it by tapering off to prevent bad withdrawals and then start the new drug when you know you're free of withdrawal symptoms.  The final possibility is that wellbutrin is one of the most stimulating antidepressant and can cause anxiety.  Usually, you'd notice this long before now, though.  But those are possibilities, and only discussing them with a psychiatrist will flesh them out.