48 rat pups were separated into 3 treatment groups: #1 – control group injected with a normal saline ethanol solution; Group #2 was injected sodium selenite (30 nmol/g body wt); and Group #3 was given sodium selenite plus resveratrol (40 mg/kg). On day 21, cataract development was graded by slit-lamp examination and photography. Encapsulated lenses and erythrocytes were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid peroxidation.
The results showed that the control group’s lenses (group 1) were clear. In group 2, all rats developed cataracts (grade 3-grade 6), whereas in group 3, only 9 of 16 rats developed cataracts (grade 2-grade 3). The difference of cataract frequency between group # 2 and #3 was statistically significant (p<0.05). Group 3 lenses and erythrocytes had higher mean GSH and lower mean MDA levels than those in group 2 (p<0.05)
The researchers concluded from their study that Resveratrol suppressed sodium selenite-induced oxidative stress and cataract formation in rats. This preventative effect was supported by greater GSH and lower MDA in lens and erythrocytes. The presence of oxidative stress in selenite cataract development and its prevention by resveratrol support the possibility that high natural consumption of resveratrol in food can help prevent human senile cataract. For more info, please check [url=http://stores.shop.ebay.com/Mom-E-Media]resveratrol[/url].