I have been taking Cymbalta for about a week now for fibromyalgia and they say it takes a month to start feeling the effects but they're wrong I started feeling at the second day I took it it has done wonders for me but the only side effect that I do have is no appetite. I have also noticed that I am losing some weight I haven't weighed myself but I can feel it when I put my clothes on. Has anybody lost a significant amount of weight while taking this medication?