I wonder if you might have some insight into a liver issue that I have been experiencing. I'm 26 years old now. In April 2006 I contracted Hepatitis A, had about 2 weeks where I was really sick then gradually got better and regained my stamina. My LFTs were very slow to return to normal. At the end of that summer I started getting repeated sinus infections, then started intermittantly wheezing. I moved across the country to go to graduate school in August 2006. When my new doctor took blood for labs, my liver enzymes were again elevated, and a Hep panel in Oct 2006 still showed positive for Hep A, Ultrasound at that point looked good and all the enlargment I had in my liver and spleen had gone away. My asthma/allergy problems continued to worsen, and I was finally diagnosed with Churg Strauss Syndrome, I have never been off steroids since then. My liver is involved in the CSS, with areas of necrotizing granulomas found on biopsy. Last december, my gallbladder decided to stop functioning properly (ejection fraction of only 8%) and so it was laproscopically removed Dec 19. I had LFTs and another Hep panel at that point and everything was okay except a slight elevation in my AST, Hep panel was negative. Since then I've been tried on methotrexate in order to reduce my prednisone dose, but that made my liver enzymes skyrocket and I was quickly taken off of it. Bloodwork 3 weeks ago once again showed elevated LFTs and a Positive Hep A result. My doctor thinks that I was never able to produce the antibodies against the Hep A and that my negative reading in december was an issue of lab range differences. If that's the case, would the liver be able to produce them while the immune system is being suppressed? Is there any medications that can help it. It's very frustrating to watch my breathing deteriorate and not be able to do anything about it because of the liver. I would appreciate any insight you have.