Possible resistance/high tolerance to all medicines???

[Some1nabox]

For quite some time now my body has been reacting differently to medicines. Put simply, it takes a much stronger dosage to have the desired effect - if at all. Other times, as is the case with IV medicines, the intended effects are achieved, but only last for an extremely short amount of time. (I.e. Morphine or Dilaudid - lasting 30 mins; Benadryl, Phenergan, Zofran, etc.- lasting 1 hr.) This has been the case relatively recently with seemingly all medicines I have taken, no matter the form. This would also include ibuprofen, acetaminophen, antibiotics and steroids. They are no longer as effective as they once were - again: if at all.

In addition, I have found that I am able to consume several times the amount of alcohol that I once was capable. Please note, that I was NEVER and am currently NOT a heavy drinker. In fact, there are only a handful of times in my life that I have ever been more than "buzzed", and I rarely consume alcohol now. I discovered my tolerance quite by "accident". Initially, a girlfriend and I were having a girl's night (first one in MONTHS) and we decided to do shots. Since I cannot stomach her drink of choice, I brought my own. After the first two shots, I felt nothing. This was very odd for me. Two years ago I was considered a "light weight" and it isn't like my alcohol consumption has changed in that time. So I took another and waited. Then another. And another. Eventually, I had consumed the entire bottle of 80 proof top shelf whiskey, before I began to feel the effects that I would normally feel after three or four shots. I felt no more than a slight intoxication. I can also assure you that this isn't a case of simply "feeling" fine, when intoxicated. Due to my anxiety, I am hyper-aware of my actions and how I feel. This is also why I do not like to get "drunk", "messed up", or "high" - and thus correlates to the number of times I have been very "intoxicated".

The only reason I continued drinking was for medical curiosity. If I had began to feel the effects sooner, I would have stopped immediately. But as I stated, I was able to drink and entire 750 ml bottle of 80 proof whiskey, with minimal effects.

I am truly having a hard time understanding how my tolerance could suddenly increase to that extreme. Especially since, when I was younger (am currently  >30 yr old) I did my fair share of social drinking. Yet, I never had such a tolerance. After I had children, for obvious reasons, my tolerance from my social drinking years went down. So what would make my alcohol tolerance shoot up suddenly?

Furthermore, what would correlate with an increased resistance to most medications?

Any professional insight would be greatly appreciated. I have mentioned this to my doctors before (about medications) and was blown off. I was treated as if I was crazy. Rather frustrating. I'm not trying to make anyone's job more difficult. On the contrary, I am trying to identify an obstacle standing in the way of my care. I feel that if we can remove this, my outcome will be much better

(A little background information: I suffer from chronic pain - related to progressive scoliosis, Degenerative Disc Disease, Osteoarthritis, Idiopathic immunodeficiencies, Hashimoto's Thyroiditis, and a seizure disorder. There may be one condition contributing to all of these symptoms, or they just as easily could be co-morbid.I see several specialists, along with my PCP. So, at times my care is rather segregated and all of them are still looking for a definitive DDX.)