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Seroconversion
I want to understand this. Doctors at medhelp say 12 weeks or even less is conclusive for HIV testing. The body experts point to 3 months as conclusive. International guidelines go for 12 weeks also, some for 6 weeks.
I checked some of the seroconversion panels for the Abbott Architect HIV Ag/Ab Combo assay and some other 4th and 3rd generation HIV tests and i found that some panels were negative at 3 months and became positive later on. You can check it here:
http://www.zeptometrix.com/hivseroconversion.htm
We are talking about 37 samples from which more than 3 were positive after 12 weeks. Put this in a large scale population and maybe 3 months are not enough.
Can someone clarify this?
I checked some of the seroconversion panels for the Abbott Architect HIV Ag/Ab Combo assay and some other 4th and 3rd generation HIV tests and i found that some panels were negative at 3 months and became positive later on. You can check it here:
http://www.zeptometrix.com/hivseroconversion.htm
We are talking about 37 samples from which more than 3 were positive after 12 weeks. Put this in a large scale population and maybe 3 months are not enough.
Can someone clarify this?
You're talking about official guidelines that have a LOT of research backing them. Do you think they just draw numbers out of a hat? How do you think they come up with those figures? By studying the disease and its trends since the start of the virus. DECADES of research.
A lot of health care providers (including our own docs here) think that the 3 months is actually too conservative, and state that people do not have to test beyond 6, 8 weeks (not that I'm in agreement of that), and YOU are trying to argue that it isn't conservative enough.
I didn't read your link, but I'm guessing somehow you're misinterpreting the data. The window period was changed from 6 to 3 months back in 2004. Agencies like FDA and CDC are not going to EVER change their guidelines unless they are SURE. Could you imagine the liability?
If YOU personally want to believe that 3 months isn't enough time, then if you have a risk, test to 6 months. It's quite simple.
A lot of health care providers (including our own docs here) think that the 3 months is actually too conservative, and state that people do not have to test beyond 6, 8 weeks (not that I'm in agreement of that), and YOU are trying to argue that it isn't conservative enough.
I didn't read your link, but I'm guessing somehow you're misinterpreting the data. The window period was changed from 6 to 3 months back in 2004. Agencies like FDA and CDC are not going to EVER change their guidelines unless they are SURE. Could you imagine the liability?
If YOU personally want to believe that 3 months isn't enough time, then if you have a risk, test to 6 months. It's quite simple.
This thread is closed. If you feel you have a risk, and want to test out longer than 3 months, that is certainly your choice, but the guidelines all say no longer than 3 months. Many experts, including all of our own, believe it is much sooner.
Debating it isn't going to change that, so this thread is closed.
Emily
************************* CLOSED THREAD **************************
NO MORE POSTS, PLEASE
Debating it isn't going to change that, so this thread is closed.
Emily
************************* CLOSED THREAD **************************
NO MORE POSTS, PLEASE
I really did not understand your point. can you clarify.
to ease the people mind do you still believe 3 month is a conclusive after seeing this like. I'm really asking to help my self and all other people that might pace us all
to ease the people mind do you still believe 3 month is a conclusive after seeing this like. I'm really asking to help my self and all other people that might pace us all
I agree you don't write the guidelines, i just wanted you to look at those panels, obviously you don't have an answer.
I'm posting this question at The Body for 2 HIV specialists. I hope they have an answer.
I'm posting this question at The Body for 2 HIV specialists. I hope they have an answer.
I had a DUO test at 4 weeks,it was negative and I moved on because I trust science & HIV specialists.
This is a forum for risk assessment. We've had these same conversations over and over. Search the forum for answers if you're interested.
We didn't make the guidelines, perhaps address your question to the FDA and manufacturers of the tests and the CDC.
We didn't make the guidelines, perhaps address your question to the FDA and manufacturers of the tests and the CDC.
I agree with you, p24 only drops as antibodies appear, so, there is no gap for the duo test.
I also want to believe Dr. Handsfield, Dr. Sean and Dr. Jose Garcia are correct. But i'm still doubtful, those seroconversion panels are something to worry about.
I also want to believe Dr. Handsfield, Dr. Sean and Dr. Jose Garcia are correct. But i'm still doubtful, those seroconversion panels are something to worry about.
Yes I do agree with that but like with anything associated with HIV there are some people that believe p24 antigen drops to undetectable levels,me personally I don't believe it does & it will remain constant throughout the illness.I would just read what our expert doctors here at medhelp have to say about latent seroconversion--they call it an urban myth,they also say the DUO is conclusive at 4 weeks+ and we have to remeber that doctors like Dr Handsfield & Dr Garcia have many years experience in these matters of HIV window periods.
The link above is from one of several companies that sells the seroconversion panels to the companies who develop the tests. Most of this seroconversion panels are from healthcare workers, that's why bleeding date is always 0, because they know exactly when infection took place.
You really can't say DUO test is good only from 1 week to 4 weeks, p24 antigen goes away as antibodies atach to it. Once a duo test becomes positive it stays positive.
You really can't say DUO test is good only from 1 week to 4 weeks, p24 antigen goes away as antibodies atach to it. Once a duo test becomes positive it stays positive.
A 4th generation DUO test is only good from week 1 to week 4 post--exposure.We don't comment on other websites and the links they provide.The official HIV window period was changed from 6 months to 3 months back in 2004,now if you are still living in the past then it's not a concern of this forum.
but the table includes (4TH GEN HIV-Ag/Ab COMBO). this table look really weird or what ?
The link above contains seroconversion panels tested with the new 4th generation HIV tests. I still don't see someone explaining the positive samples beyond 12 weeks...
Latent seroconversion past 3 months happened over 20 years ago when HIV testing was poor,we have better,more sensitive testing now.
we really need to understand this link, can the experts say something.
http://www.zeptometrix.com/hivseroconversion.htm
We are talking about 37 samples from which more than 3 were positive after 12 weeks. Put this in a large scale population and maybe 3 months are not enough.
http://www.zeptometrix.com/hivseroconversion.htm
We are talking about 37 samples from which more than 3 were positive after 12 weeks. Put this in a large scale population and maybe 3 months are not enough.
Fine, then someone please explain why there are positive seroconversion panels beyond 12 weeks on the above link
According to the CDC, most people infected with HIV will develop detectable antibodies within 25 days of exposure and 97% of people will have HIV antibodies by three months after exposure.
is this true ?. why just 97% is't conclusive by 3 months ?
is this true ?. why just 97% is't conclusive by 3 months ?
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