What can cause a moderately enlarged heart, but normal ejection fraction. I also have almost normal Pulmonary Artery Pressure at 20.48. I did have large PE's six years ago, but they have since cleared out. I have high blood pressure spells when standing, normal BP when sitting. I get fast heartbeat sometimes also. I can get a heart rate of 130 BPM just from grating cheese. I am on BP meds to control the high BP when standing. Without meds, my BP can go from 116/78 when sitting to 170/120 just from standing up and walking around. The ER doc said it could be a heart issue causing this and send me for the Echo. The Cardiologist will not even take into consideration my high BP when standing as he says you can only get low blood pressure from standing, not high. My PCP is also stumped and called it liable hypertension. Even with 20-50 mgs of Lisinopril and .2 mgs of Clonidine, my BP will still jump to 130/95 when standing. I have caught my heart rate dropping to the 40's before and also sometimes my oxygen levels drop when walking or doing work. They quickly bounce back up again though. I failed a lung function test two years ago. I had low FEV1/FVC and low DLCO gas exchange. It showed both a restrictive and obstructive pattern, but my HRCT scan of lungs showed normal looking lungs. I also had my oxygen drip to 91 during a 6MWT on the pulmonary doc's 02 meter. So, I know it's not just a fluke with my meter. What do you think this can be from? Also, can taking Lisinopril and Clonidine cause my Pulmonary Artery Pressures to be lower? I have never felt the same since large PE's. I had a VQ scan to rule out chronic clots in the lungs and it came back normal. Can there be gas exchange problems in the lungs that do not show up as ventilation and profusion defects on a VQ scan? I feel tired all of the time. More tired than these issues should make me feel. Sometimes I wonder if I'm a hypochondriac and should just ignore all of this stuff.