Can the total MPO blood value be made up of other factors besides cardiac ones?

[ceachell]

A patient has a MPO result of 600.  Granted, primary concern is a cardiac one.  However, we know that periodontal disease, chronic sleep deprivation and chronic rhinitis can cause MPO elevations as well. From a simplistic point of view, might the 600 value be made up of also non-cardiac concerns?

Thanks for asking the question. I am having the same issues, my MPO was 2,772.  I have about 25 pounds to lose, workout a 3-4 days a week, but don't have the best eating habits. I am scared to death about my MPO number. Hope yours turns out well. Praying for you.

[ceachell]

I 'Tip My Hat To You!"  Your response provided the means to research this on the web.  An excellent study was reviewed, and with your information, the puzzle pieces came together.  You've probably assumed by now the issue is a personal one.  A second round of blood testing by Cleveland Lab up on Feb. 19 with a physician follow-up soon to follow.
      
Before then, I needed to research info. for an intelligent question/answer discussion to follow. Thanks to you, I feel much more confident now to do this.

The above referenced study was excellent and can be found at:  http://www.clinchem.org/content/57/1/33.full.

ceachell

[Occupant]

I would think that they are talking only about the specific MPO test patented by the ClevelandHeart Lab.

[ceachell]

Thanks very much for your quick response.  As per the ClevelandHeart Lab, a value of greater than or equal to 480 pmolL defines a high risk population for a cardiovascular event based on the 97.5%ile. "The event" is described elsewhere, but one of the events listed is death. As per ClevelandHeart, MPO levels should be measured even in asymptomatic individuals.

Just imagine the effect these words are having on the general population!  In our example, if the MPO value of 600 could be reduced close to 479 (ClevelandHeart Lab value for "apparently Healthy" population at low risk for a cardiovascular event) by other MPO elevators such as  periodontal disease, chronic sleep deprivation, etc., patients would be greatly relieved.

Of course, emphasis will be placed on cardiac issues and what can be done to improve the risk factors of the patient.  But, let's provide them with a realistic view of the MPO values.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

[ceachell]

I'm sorry.  I have no idea.

[Flycaster305]

is this related to what I'm tested for, IBN, to determine CHF?  

[ceachell]

Thanks for your response.  MPO refers to Myeloperoxidase, a white blood cell-derived inflammatory enzyme whose level is being associated with an increased risk for cardiovascular disease and myocardial infarction.  Relative risk:  Low less than 480 pmol/L and High:  greater than 480 pmol/L.

[Flycaster305]

What is MPO?