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What's the better treatment tenofovir or entecavir?
Which one is better treatment for chronic hbv, tenofovir or entecavir? I am currently hbsag + and hbsag-. If I were given a choice of treatment or go on treatment, which one should I ask for? I am sure my hepatologist will advice me well, but would like a heads up. Anybody have experience or knowledge of these two treatments? I been reading the articles, but still new to this and it sounds good on both ends. Which is better in your opinion?
I am sure my doctor has his means of which would be better for me? Thx
I am sure my doctor has his means of which would be better for me? Thx
Do you mean that meds such as entecavir can be stopped completely once hbsag gets to those amounts?
and also hbsag clears stopping antivirals when very low, dont remember exactly the limit to clear
they can also be safely stopped when hbsag is less than 300-400iu/ml
they can also be safely stopped when hbsag is less than 300-400iu/ml
Once you started antivirals you have to take it forever unless you get cleared . You can see your HBV DNA undetectable after taking antiviral but you do not know your HBSA level because it is not tested in USA. In other countries, patients have chance combo treatment with interferon if HBSA is <1000 (good chance to clear for some people). However, PEG is not ordered in USA even there is HBSA quantitive test. If you stop taking, hbv may reactivate again. So, we have no other choice other than continuing antivirals and waiting and praying for new treatment for clearance. May be one sunny day, some of us get that opportunity.
So what happens to people who gets on treatment in their 30s or 40s or even 50s. Would they have to take if for 20 to 30 possibly 40 years??? And if they are not able to, then what would happen? How realistic is treatment for hbv, in the long term? Any opinions?
Hard to tell. They both have many side effects. Entecavir you have to wait 2 hours before and after meals.
Another important component in the US is insurance. If you find after monitoring you may benefit from antivirals, most doctors here would say either would work. If going for Viread they will test kidney's first. For those with prior Lamivudine then Entecavir may have resistance, so may recommend Viread from the start. Since you would be treatment naïve most doctors will not have a preference, your insurance may be the one to make the final call, depending on plan Formularies, Prior Authorizations, and co-pay levels.
Tdf is better for 0 resistance but if you have kidney issues etv will be better suited. Don't be in a hurry to take nucs, they create other issues. Take only if you have to. If you can wait for taf it is suppose to be better than tdf and less harsh on kidneys and bone loss.
Test your kidneys, if kidneys are ok then tenofovir would probably be a better option, if kidneys not ok then entecavir
if your kidneys are healthy and not damaged tenofovir is the most potent nuc on hbsag
Tdf is not usually finite treatment neither is etv.
it can depend on kidney functiom weather tdf is suitable.
In general for NUCS it depends on viral loads and liver function tests aswell
it can depend on kidney functiom weather tdf is suitable.
In general for NUCS it depends on viral loads and liver function tests aswell
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