Just got my genotype result back...

[itac]

See photo attached.

Can someone explain what does BCP mutations mean?
Also, is this genotype considered better to treat or more chances to seroconvert?
Where is the origin of D in the world?

Thanks!

[stef2011]

do you think micro rna tests done in pisa can help understand what gcmaf/high dose vit d3 is doing on the immune system both combo with peg or combo with tdf?

researchers there were not so interested in gcmaf/vitd, they agreed it helps and it was ok to do but since it is too difficult to see what he does combo with tdf or peg, they were never interested to check deeply

is it possible that micro rna tests theyhave now can show changes in hbv immune response when on gcmaf/high dose vitd and off of it while on tdf?

[sorte]

So smaller viral load may give better response to the interferon ? Even if hbsag is quite high ?
In what stage of interferon treatment some detectable antibodies may appear ? When viral load is und or only after loosing HBsAg ?
One question a bit out of the topic, why spontaneous seroconversion usually happends after many years of infection (I saw in one Taiwan study, it was around 40 years old persons) when virus should be well adapted already.
Thanks for all explanations.

[mike9111]

Thank you the good thing for me is that my wife is german sonwe are planing to visit her parents in winter and will take that as an opportunity to retest. I tried to test for mutant but seems my doctor see no clinical interest to test for mutation

[studyforhope]

the hbsag quant does not normally fluctuate more than 10 or 20%, unless something has changed in the cytokine milieu of the liver.
It is a shame that you have to fly to Germany to get such a simple test done. Also, monitoring during the treatment would be of interest. i don't think they do it in Canada yet, (since you are in Michigan).

[mike9111]

Thank u so much for taking ur time to explain. i will run another hbsag quantitative test in december when i fly to germany and if it remain low then will ask for peginterfron. Last question does hbsag quantitative fluctuate or usually stable?

[studyforhope]

If the pressure is high enough and the destruction of remaining genomes is fast and complete enough, the adaptive power of the system can be overcome. It is a difference if you make one trillion or 10 million fresh virions per day.
Plus, once the hbsag is finally produced in only such small amounts that the antibody is not complexed away but has an effective level, de novo produced virions will be captured and neutralized once they leave the hepatocyte and their mutations are irrelevant.  An effective antibody contains the spreading of mutations and reinfection dramatically and also consequentially the further adaptive power of the system.