I am not a doctor. Your series of data on your viral load and AFP are very good, but they are insufficient to allow readers to comment. At the minimum, you will need to post your ALT, AST, HBeAg status and whether you were on treatment or stopped. Other data like serum HBsAg and fibrosis will also be useful. At one stage, your hbvdna is undetectable, which is good. But your latest hbvdna is > 2,000 iu/ml. As a guess, only a guess, 1) you were on antiviral treatment, then stopped when hbvdna is zero; or 2) you were HBeAg negative, in the immune control phase, and now transit to the immune escape phase which requires treatment.