How are your teeth post triple tx??

beeblessed

Knock, knock, Penny?? Knock, knock, Penny??
Hi there everyone. Haven't been on the boards in awhile, as I have been dealing with multiple health issues since tx (which failed for me). My doc doesn't think it's due to tx, since the drugs are out of my system. I am a little past 1 year post tx w/Victrelis, Peg & Riba. Because we ALL have had some ailment in our lives before tx, and because I definitely have pre-existing stuff, I don't want to jump to blame everything on the tx meds.

That said......I just found out that I need Major dental work. Multiple cavities, holes, and missing pieces of a tooth. Granted, I have not been keeping up with regular dental visits but I certainly do not believe I have done anything that would cause something so drastic. So, for the Post Treatment folks, please share if you have experienced unusual dental changes that lead you to believe it could be Interferon related, or the other tx meds. And if you have links to any fact based articles, please include those too. Quite embarrassing to think this is my doing, so if I could provide my dentist with another valid reason.... Too sleepy to research tonight.

Thanks in advance.
Sending a big HI!!! to all my old MedHelp buddies (2011-2012).
Be Blessed,
Bee :0)

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pooh55811

I am posting several links to articles which mention the teeth and dental problems associated with treatment. Each of these articles discusses the dental problems somewhere in the article, often under complications or warnings:

5.7 Dental and Periodontal Disorders

Dental and periodontal disorders have been reported in patients receiving ribavirin and interferon combination therapy. In addition, dry mouth could have a damaging effect on teeth and mucous membranes of the mouth during long-term treatment with the combination of ribavirin and interferon alfa-2b.

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9ed7adc9-bd0c-41af-b34c-43d15a7799d1

Teeth and gum disorders, which may lead to loss of teeth, have been reported when this medicine is used in combination with interferon alfa or peginterferon alfa.

http://www.netdoctor.co.uk/infections/medicines/copegus.html

This medicine may cause teeth and gum problems. This medicine may cause dryness of the mouth, and a dry mouth may damage your teeth and gums if you take the medicine for a long time.

http://www.mayoclinic.com/health/drug-information/DR602577/DSECTION=precautions-

Dental and periodontal disorders
: Dental and periodontal disorders, which may lead to loss of teeth,
have been reported in patients receiving ribavirin and peginterferon alfa-2b or interferon alfa-2b
combination therapy. In addition, dry mouth coul
d have a damaging effect on teeth and mucous
membranes of the mouth during long-term treatment with the combination of ribavirin and
peginterferon alfa-2b or interferon alfa-2b.

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/001018/WC500056547.pdf

Severe Stomatitis Complicating Treatment With Pegylated-Interferon
-2a and Ribavirin in an HCV-Infected Patient

http://health.usf.edu/NR/rdonlyres/F05CA297-F2AA-4F28-8B76-5A65378B24A6/44993/IFNStomatitis.pdf

In a Japanese Phase III trial of Peg-IFN alfa-2a and ribavirin involving 199 patients with chronic hepatitis C, including 99 patients with IFN treatment-naive genotype 1 and 100 patients with patients whom had not had a SVR after IFN therapy, the oral side effects were: gingival bleeding and gingival swelling (6%), toothache (4.5%), gingivitis and periodontitis (3%), dental caries (1.5%), stomatitis and cheilitis (19.1%), disorder of taste (15.6%), dry mouth (6.5%), glossalgia and glossitis (4.5%), perioral paresthesia (2.5%), oral pain (0.5%), oral mucosal damage (0.5%), oral lichen planus (0.5%), oral hemorrhage (0.5%), dry lip (0.5%), and bulla of lip (0.5%). On the other hand, in a Japanese Phase III trial of Peg-IFN alfa-2b and ribavirin involving 332 chronic hepatitis C patients, including 269 patients for 48 weeks treatment duration with genotype 1b and high virus load, and 63 patients for 24 weeks treatment duration with others, oral side effect were: dental pulpitis, gingivitis, and periodontitis (8.9%), toothache (7.1%), dental abnormity (1.1%), stomatitis and cheilitis (26.8%), disorder of taste (26.8%), dry mouth (15.6%), glossitis (5.9%), oral discomfort feeling (2.6%), oral hemorrhage (0.4%), oral pain (0.4%), dry tongue (0.4%), decreased secretion of saliva (0.4%).

http://www.virologyj.com/content/7/1/192

Hope this helps some.

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patra_

As I look at your post again, I see I ignored part og it- didn't mean to.

You might ask the Dr if Floride treys at this point would help preserve you natural teeth and imporve the areas under the implants.

I don't think the decay can be reversed, but, heck, ask anyway.

Hope the work you have to have done is not too extensive.

Pat

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patra_

Oops! if I typed Florida treys, I meant to type f-l-o-r-i-d-e. That blue stuff they treat your teeth with to strengthen them. Of course, Florida treys works, too,if itis filled with lucious ,oranges, mangos, papayas, etc., etc., etc., you get the picture. : -). Pat

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dontworry_behappy1

Vitamin C is really good for your gums.

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Dee1956

That is really great, I used flossing, brushing, drinking lots of water as well as the biotene products, the water pick a couple of times a day but have never heard of Florida Trays, I appreciate you sharing.

I had all this work done pre treatment, now it seems to be failing, i.e. crown margins are off so food is getting underneath and can cause decay. I have to have my crowns replaced.

I asked my dentist what I could have done to prevent these failed crowns, he said nothing.

Now that I look at this I realize I should have asked a new question.

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patra_

Last year when I was getting ready to start tx, I was on the Forum read a thread discussing dry mouth and its resulting dental problems.  My dentist happened to be in my church for Father's Day, and heard me say that I was starting tx.  He came over and asked if I had talked to my hepa about Floride Trays.  I called the hepa the next morning and was told it was a good idea.  Dentist had them made and ready so quick!  I used them faithfully, every night, all the way through 6 mo of tx w/ sol/riba.

I have had two visits one while on tx and one within a month after.  The Dentist is very pleased!  By the first visit (3 mo into tx) my gums had gone from always red and inflamed to pink and healthy!  I can't remember when that was the case.  I believe that it was a residual of INF tx in the 90s, but who knows?  Anyway, my gums were still in excellent condition a month aftex end of Tx.

I truly believe the combination of careful mouth care, including the waterpik 2 tx a day, and the floride tray every night, made a big difference.  NO gum or dental problems to date, 3 months after EOT.

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Dee1956

I am having a lot of dental problems, came on here to see what others have experienced, found this older thread so am bumping it up.
I hope that is all right.
I  found an article from 2013 that talks about how HCV can affect the mouth.
It also talks about extra hepatic manifestations.   Before I treated, I had a lot of dental work done, during tx I was so careful with my teeth but still had to have two crowns redone during tx.
I am now having to have more work redone, bad dentist or my system? I don't know.  I have great bone structure per a recent bone scan so just not sure.
Is anyone else having problems?  Thank you, Dee

http://www.journal-imab-bg.org/issue-2013/issue4/JofIMAB2013vol19b4p377-379.pdf

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