Aa
How are your teeth post triple tx??
Knock, knock, Penny?? Knock, knock, Penny??
Hi there everyone. Haven't been on the boards in awhile, as I have been dealing with multiple health issues since tx (which failed for me). My doc doesn't think it's due to tx, since the drugs are out of my system. I am a little past 1 year post tx w/Victrelis, Peg & Riba. Because we ALL have had some ailment in our lives before tx, and because I definitely have pre-existing stuff, I don't want to jump to blame everything on the tx meds.
That said......I just found out that I need Major dental work. Multiple cavities, holes, and missing pieces of a tooth. Granted, I have not been keeping up with regular dental visits but I certainly do not believe I have done anything that would cause something so drastic. So, for the Post Treatment folks, please share if you have experienced unusual dental changes that lead you to believe it could be Interferon related, or the other tx meds. And if you have links to any fact based articles, please include those too. Quite embarrassing to think this is my doing, so if I could provide my dentist with another valid reason.... Too sleepy to research tonight.
Thanks in advance.
Sending a big HI!!! to all my old MedHelp buddies (2011-2012).
Be Blessed,
Bee :0)
Hi there everyone. Haven't been on the boards in awhile, as I have been dealing with multiple health issues since tx (which failed for me). My doc doesn't think it's due to tx, since the drugs are out of my system. I am a little past 1 year post tx w/Victrelis, Peg & Riba. Because we ALL have had some ailment in our lives before tx, and because I definitely have pre-existing stuff, I don't want to jump to blame everything on the tx meds.
That said......I just found out that I need Major dental work. Multiple cavities, holes, and missing pieces of a tooth. Granted, I have not been keeping up with regular dental visits but I certainly do not believe I have done anything that would cause something so drastic. So, for the Post Treatment folks, please share if you have experienced unusual dental changes that lead you to believe it could be Interferon related, or the other tx meds. And if you have links to any fact based articles, please include those too. Quite embarrassing to think this is my doing, so if I could provide my dentist with another valid reason.... Too sleepy to research tonight.
Thanks in advance.
Sending a big HI!!! to all my old MedHelp buddies (2011-2012).
Be Blessed,
Bee :0)
I thought I would add one more thing here..... I didn't yesterday because I felt that I had already possibly gone over the top.
When I got interviewed for my trial, they had to go into the drug interview again.
It always sets me off. Here I am trying to be likeable, easy going and I went off on a minor lecture to the interviewer. I said that it appeared to me that the only data they were collecting was that supported that people acquired their infection from drugs. The focus of the survey was to collect data which supported that fact.
I said..... they didn't seem interested about any other vectors for infection, and I mentioned a few recent mass infections that had made the news that were medical practice vectors.
Please believe me..... I hold similar values. The nurse..... just said that essentially....she was just the messenger.... she had to go through this for the trial sponsor.....and we moved on. I had made my point I think.
Yesterday afternoon it occurred to me again..... every single medical person I've come across has touched on that topic. I think that they favor that topic so as to take some of the emphasis off of the medical field as a vector.
Willy
When I got interviewed for my trial, they had to go into the drug interview again.
It always sets me off. Here I am trying to be likeable, easy going and I went off on a minor lecture to the interviewer. I said that it appeared to me that the only data they were collecting was that supported that people acquired their infection from drugs. The focus of the survey was to collect data which supported that fact.
I said..... they didn't seem interested about any other vectors for infection, and I mentioned a few recent mass infections that had made the news that were medical practice vectors.
Please believe me..... I hold similar values. The nurse..... just said that essentially....she was just the messenger.... she had to go through this for the trial sponsor.....and we moved on. I had made my point I think.
Yesterday afternoon it occurred to me again..... every single medical person I've come across has touched on that topic. I think that they favor that topic so as to take some of the emphasis off of the medical field as a vector.
Willy
Again, I apologize and appreciate those who have already accepted my apology!
If you know me from this site I really do not mean any harm. This treatment has done me such harm and I have very few next to me that understand and can give support... but then as has been said so many times even the liver gurus "seemingly" dont understand what is going on with their own treatment?!?!?!?!?!
I do really try to keep a positive attitude on everything but when it comes down to it all I really am pretty pissed about the life they took away from me (and many of the good people here).
I think a hellava lot of research should have gone into treatment or at least now that so many have gone thru it all at least it should be time to spend some of the multiple millions on long term problems some people have with treatment.
btw, Hey willy!
frank
If you know me from this site I really do not mean any harm. This treatment has done me such harm and I have very few next to me that understand and can give support... but then as has been said so many times even the liver gurus "seemingly" dont understand what is going on with their own treatment?!?!?!?!?!
I do really try to keep a positive attitude on everything but when it comes down to it all I really am pretty pissed about the life they took away from me (and many of the good people here).
I think a hellava lot of research should have gone into treatment or at least now that so many have gone thru it all at least it should be time to spend some of the multiple millions on long term problems some people have with treatment.
btw, Hey willy!
frank
That's Ok Frank. I think I was being over-sensitive. I guess I took the high road, when I also saw the low road.
I'm not sure what I look like with my ever-bleeding gums and ghostly pasty face. I have to swill and spit before I get out of my car and go anywhere. Smiling is a limited option.
Willy50.
I get it. I did bandwagon jump a little. I can cut all ways.
I'm not sure what I look like with my ever-bleeding gums and ghostly pasty face. I have to swill and spit before I get out of my car and go anywhere. Smiling is a limited option.
Willy50.
I get it. I did bandwagon jump a little. I can cut all ways.
What floors me about all of this is that it is obviously known, and has been know for some time, that Interferon and Riba cause dental problems but it seems that very few medical and/or dental people know it. If those medical people we go to for treatment were better informed about the side effects of the drugs they are using to treat us, maybe, just maybe, some of the dental problems (as well as other problems) could be prevented (although I doubt all of it could be prevented).
I also tried very hard to keep my teeth and gums in shape during Tx but the dry mouth was dry as a bone no matter what I did. I often could not swallow because my throat was so dry. I drank water all of the time and 1 minute after taking a few gulps of water, I was parched. I used Biotene too but I still had a dry mouth.
I wish I knew then (starting Tx) what I know now. Treatment would have been easier.
I also tried very hard to keep my teeth and gums in shape during Tx but the dry mouth was dry as a bone no matter what I did. I often could not swallow because my throat was so dry. I drank water all of the time and 1 minute after taking a few gulps of water, I was parched. I used Biotene too but I still had a dry mouth.
I wish I knew then (starting Tx) what I know now. Treatment would have been easier.
I don't have any research on hand but there is abundant general knowledge of interferon causing dry mouth (I'm pretty sure it is a universal sx), and I think any halfway decent dentist will immediately connect dry mouth with dental decay. The two different dentists my husband and I see both made that connection instantly. I did use Biotene regularly throughout my tx and it helped a lot with the discomfort of dry mouth but didn't help enough to prevent decay. Well, it may have prevented some - perhaps it would have been worse without the Biotene. After the cavities were found by my dental hygienist she gave me a fluoride gel to apply at night after brushing (while waiting to get the appointment for fixing them), and said it would have prevented them if I'd used it during tx and what a shame they hadn't known to prescribe it. On the other hand, I had so many problems during tx that I probably couldn't have handled one more slightly unpleasant thing!
p.s. Bee, you hold a special place for me, as you were the first to help me when I made my first botched attempt at posting on this forum (instead of the forum I somehow posted on your journal by mistake). Thank you for your guidance then.
p.s. Bee, you hold a special place for me, as you were the first to help me when I made my first botched attempt at posting on this forum (instead of the forum I somehow posted on your journal by mistake). Thank you for your guidance then.
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5.7 Dental and Periodontal Disorders
Dental and periodontal disorders have been reported in patients receiving ribavirin and interferon combination therapy. In addition, dry mouth could have a damaging effect on teeth and mucous membranes of the mouth during long-term treatment with the combination of ribavirin and interferon alfa-2b.
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9ed7adc9-bd0c-41af-b34c-43d15a7799d1
Teeth and gum disorders, which may lead to loss of teeth, have been reported when this medicine is used in combination with interferon alfa or peginterferon alfa.
http://www.netdoctor.co.uk/infections/medicines/copegus.html
This medicine may cause teeth and gum problems. This medicine may cause dryness of the mouth, and a dry mouth may damage your teeth and gums if you take the medicine for a long time.
http://www.mayoclinic.com/health/drug-information/DR602577/DSECTION=precautions-
Dental and periodontal disorders
: Dental and periodontal disorders, which may lead to loss of teeth,
have been reported in patients receiving ribavirin and peginterferon alfa-2b or interferon alfa-2b
combination therapy. In addition, dry mouth coul
d have a damaging effect on teeth and mucous
membranes of the mouth during long-term treatment with the combination of ribavirin and
peginterferon alfa-2b or interferon alfa-2b.
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/001018/WC500056547.pdf
Severe Stomatitis Complicating Treatment With Pegylated-Interferon
-2a and Ribavirin in an HCV-Infected Patient
http://health.usf.edu/NR/rdonlyres/F05CA297-F2AA-4F28-8B76-5A65378B24A6/44993/IFNStomatitis.pdf
In a Japanese Phase III trial of Peg-IFN alfa-2a and ribavirin involving 199 patients with chronic hepatitis C, including 99 patients with IFN treatment-naive genotype 1 and 100 patients with patients whom had not had a SVR after IFN therapy, the oral side effects were: gingival bleeding and gingival swelling (6%), toothache (4.5%), gingivitis and periodontitis (3%), dental caries (1.5%), stomatitis and cheilitis (19.1%), disorder of taste (15.6%), dry mouth (6.5%), glossalgia and glossitis (4.5%), perioral paresthesia (2.5%), oral pain (0.5%), oral mucosal damage (0.5%), oral lichen planus (0.5%), oral hemorrhage (0.5%), dry lip (0.5%), and bulla of lip (0.5%). On the other hand, in a Japanese Phase III trial of Peg-IFN alfa-2b and ribavirin involving 332 chronic hepatitis C patients, including 269 patients for 48 weeks treatment duration with genotype 1b and high virus load, and 63 patients for 24 weeks treatment duration with others, oral side effect were: dental pulpitis, gingivitis, and periodontitis (8.9%), toothache (7.1%), dental abnormity (1.1%), stomatitis and cheilitis (26.8%), disorder of taste (26.8%), dry mouth (15.6%), glossitis (5.9%), oral discomfort feeling (2.6%), oral hemorrhage (0.4%), oral pain (0.4%), dry tongue (0.4%), decreased secretion of saliva (0.4%).
http://www.virologyj.com/content/7/1/192
Hope this helps some.