Aa
Ribovirin in the fridge
I accidentally put my ribovirin in the fridge x 5 days before I started treatment. It came on ice and the pharmacy that sent it stuck some label over the "how to store instructions" on the box. I am worried that the medicince is not working because of the wrong storage x 5 days. Any advice?
Sorry for the remark....you are correct...i maybe should not have posted that info on the rib with no food....i just thought someone would wonder about it ...i really cant control all read and post...BUT i try....thax for poiting thta out...again....sorry bout the rag remark
wishing you well
wishing you well
How about a person who has severe fatty liver and is over weigh and cirrrotic and wants to tx...should one take a high fat food with riba?....maybe not...just my thougts
Effects of Food and Antacid on Bioavailability
Two studies have been carried out to assess the effect of food (ie, a high-fat breakfast) on the bioavailability of single oral doses of ribavirin (Table 2). An initial study by ICN Pharmaceuticals, Inc. (Costa Mesa, Calif)[19] showed minor effects on bioavailability, but a 33% increase in Tmax. A subsequent study by Schering-Plough Corporation (Kenilworth, NJ)[6] demonstrated more substantial increases in bioavailability: food increased the AUC and Cmax by 70% relative to the fasted population, and Tmax was more than doubled.
Although both studies consistently showed that food slowed the absorption of ribavirin, the extent to which food affected ribavirin bioavailability differed widely between the studies. It is also unknown whether any food effect might be altered by the type of meal consumed (eg, high versus low fat), if a food effect would still be evident upon multiple dosing of ribavirin, and, finally, what clinical implications the food effect might have. It should be noted that in the pivotal Schering-Plough clinical efficacy studies, ribavirin was administered without regard to food. Because of the uncertainty about the effects of food, it may be prudent for patients to take ribavirin with food; if toxicity (anemia) occurs, this can be managed by ribavirin dose reduction.
Coadministration with an antacid containing magnesium, aluminum, and simethicone (Mylanta®, Johnson & Johnson · Merck, Fort Washington, Pa) reduced the bioavailability of ribavirin (mean AUC reduced by 14%; Cmax reduced by 3%).[6] This change is unlikely to be of clinical relevance.
Two studies have been carried out to assess the effect of food (ie, a high-fat breakfast) on the bioavailability of single oral doses of ribavirin (Table 2). An initial study by ICN Pharmaceuticals, Inc. (Costa Mesa, Calif)[19] showed minor effects on bioavailability, but a 33% increase in Tmax. A subsequent study by Schering-Plough Corporation (Kenilworth, NJ)[6] demonstrated more substantial increases in bioavailability: food increased the AUC and Cmax by 70% relative to the fasted population, and Tmax was more than doubled.
Although both studies consistently showed that food slowed the absorption of ribavirin, the extent to which food affected ribavirin bioavailability differed widely between the studies. It is also unknown whether any food effect might be altered by the type of meal consumed (eg, high versus low fat), if a food effect would still be evident upon multiple dosing of ribavirin, and, finally, what clinical implications the food effect might have. It should be noted that in the pivotal Schering-Plough clinical efficacy studies, ribavirin was administered without regard to food. Because of the uncertainty about the effects of food, it may be prudent for patients to take ribavirin with food; if toxicity (anemia) occurs, this can be managed by ribavirin dose reduction.
Coadministration with an antacid containing magnesium, aluminum, and simethicone (Mylanta®, Johnson & Johnson · Merck, Fort Washington, Pa) reduced the bioavailability of ribavirin (mean AUC reduced by 14%; Cmax reduced by 3%).[6] This change is unlikely to be of clinical relevance.
Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters.
http://en.wikipedia.org/wiki/Ribavirin
http://en.wikipedia.org/wiki/Ribavirin
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