Boce and Resistance

[nygirl7]

They also noted that about a quarter of blood samples taken from the patients showed signs of viral resistance against boceprevir. "

That's not so good but Schiff is very enthusiastic about the effort to improve HCV treatment.... Still that number seems pretty high and I'd not be jumping into trials without taking it into consideration.  As exciting as the PIs may be jumping into the frey and then not succeeding might be one reason to try SOC first. Just my opinion. I dont know the number on Tela resistance.

http://www.businessweek.com/lifestyle/content/healthday/641922.html

[Deb9991]

It is still a respectable improvement over SOC for G-1s than the 50% level of achieving SVR before Boceprevir.  It seems like medical science is moving slowly, but on a historical scale, it is actually moving rapidly.  Also, even for those people who do not achieve SVR, there is some impoverment in their conditions, allowing them to wait it out for more advanced medications in the pipelines.  Think about consumption (tuberculosis), a scourge that killed countless millions of people over the ages -- or small pox, or the Black Plague (Bubonic Plague) in the Middle-Ages that wiped out a quarter of the population in Europe.  All that considered, great things are happening and those who have not achieved SVR yet, have a lot to look forward to.  SOC as it is now, is much better than it was ten years ago.  Awareness of Hep C is doing a lot to educate the public and more and more people are getting tested and treating earlier.  These are promising days in which we live.  Who knows what ten years will bring -- it could be miraculous, in fact, it is now, considering the improvements that have been made.  

Debbie

[spectda]

25% of the samples showing resistance makes sense since the success rate is close to 70%. If you don't svr with it I think most likely you had resistance.

[Trinity4]

I'm liking Telaprevir results more than Boceprevir these days.  I've always thought ideally I would  treat again with Boce but not so sure now.  With each of them there is going to be a certain amount of viral resistance and maybe because I've seen more statistics on Telaprevir results than I have on Boceprevir is the reason I'm thinking this way.

Hell, when it's all said and done I'll be glad to get either one of them.

Trin