Aa
Boceprevir Notes
Participants were randomly allocated to various regimens containing 800 mg twice-daily boceprevir, HEY,,,in the trial im in ill be taking 800 mg 3 times a day...maybe this will boost my chances.
Hi!
I see you are in Il. I was diagnosed with HepC last week. I caught NCT00705432 in somebody else's post so I called today. I have no idea what stage I am in and have only just come to terms that this is serious. Thay are going to call me back in the next couple of days. I was wondering if you and I could chat somehow and give me a little clue.On the phone,the nice voice told me that the info was not showing in their system on this trial.
Thanks for any input.
Karen aka smiley =)
I see you are in Il. I was diagnosed with HepC last week. I caught NCT00705432 in somebody else's post so I called today. I have no idea what stage I am in and have only just come to terms that this is serious. Thay are going to call me back in the next couple of days. I was wondering if you and I could chat somehow and give me a little clue.On the phone,the nice voice told me that the info was not showing in their system on this trial.
Thanks for any input.
Karen aka smiley =)
Rock: Treating without riba is like flying with a broken wing...what were these guys smokiing back then?.
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The trial you cited above -- with a no riba arm -- was presented fairly recently. The idea was to see if the addition of a PI would work without riba. Telaprevir did same thing in their earlier trials but I think dumped the concept for now. Not sure if Boceprevir has done similar since. No one was smoking anything, just a legitimate attempt to test a concept which would help make treatment less toxic and more tolerable to many.
You may or may not know that riba wasn't initially used with interferon as well. They just didn't know it would help in the early days. SVR figures without ribavirin were around half as with the interferon used in those days. Something around 20% SVR I think without riba.
My guess is that in 5-10 years someone will post here "Treating without a Protease Inhibitor is like flying with a broken wing ...what were these guys smokiing back then? And in 20 years hopefully this place won't exist because hopefully there will be both a simple cure and a vaccine for HCV.
-- Jim.
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The trial you cited above -- with a no riba arm -- was presented fairly recently. The idea was to see if the addition of a PI would work without riba. Telaprevir did same thing in their earlier trials but I think dumped the concept for now. Not sure if Boceprevir has done similar since. No one was smoking anything, just a legitimate attempt to test a concept which would help make treatment less toxic and more tolerable to many.
You may or may not know that riba wasn't initially used with interferon as well. They just didn't know it would help in the early days. SVR figures without ribavirin were around half as with the interferon used in those days. Something around 20% SVR I think without riba.
My guess is that in 5-10 years someone will post here "Treating without a Protease Inhibitor is like flying with a broken wing ...what were these guys smokiing back then? And in 20 years hopefully this place won't exist because hopefully there will be both a simple cure and a vaccine for HCV.
-- Jim.
Treating without riba is like flying with a broken wing,,,,WILL NOT WORK...what were these guys smokiing back then?...i wonder if anyone got SVR without the riba?
"What does it mean when they say, 'some with Ribavirin'? "
That's exactly what it means, that in some of the arms they used no Riba. But that was on the earlier trials.
Co
That's exactly what it means, that in some of the arms they used no Riba. But that was on the earlier trials.
Co
Susan...you have to get ii on one of the BOC trial coming up...your odds are way better....maybe we can do a bonny an clyde and rob all the BOC...i bet i would have no problems selling that stuff...id put the crack dealers outta business
From what i see all the trials by BOC in the past used riba...but some past trials used lower doses of riba...i think they were a fixed does at 800mg a day...they proved the more riba with the BOC is more effective..duhhh...waht gave these guys the first clue?...L;OL...IM ON 1200 MG RIBA a day
What does it mean when they say, 'some with Ribavirin'? Does that mean that they have a group that is not using the Riba? If I ever did get into that trial, I most certainly wouldn't want to get placed into another 'no Riba' group, as I did in the Prove 3 trial! Please explain if you no what they mean by that.
Susan400
Susan400
Null Responders
In a related study, researchers looked at response to boceprevir combination therapy in 357 "null responders" with genotype 1 HCV who had less than a 2 log10 drop in HCV RNA after 12 weeks of prior treatment with pegylated interferon/ribavirin, or failure to achieve undetectable viral load if treated longer than 12 weeks.
Participants received 1.5 mcg/kg/week pegylated interferon (PegIntron) plus boceprevir at doses of 100, 200, 400, or 800 mg, some with ribavirin. The control arm received standard therapy, adding boceprevir if HCV remained detectable. Early data showed that the lower doses of boceprevir were less effective, so all patients who demonstrated virological response to boceprevir switched to triple combination therapy using 800 mg boceprevir for an additional 24 weeks.
SVR rates ranged from 2% in the control group to 14% using the boceprevir regimens studied, though no patients received triple therapy with the highest dose of boceprevir for the full treatment period. Individuals who experienced a viral load decrease greater than 2 log10 at week 12 were most likely to achieve undetectable HCV RNA on triple therapy. Boceprevir resistance mutations were detected in a majority of subjects who did not achieve SVR.
The investigators concluded that, "Some 'null' responders to [pegylated interferon/ribavirin] can achieve an SVR with [pegylated interferon/ribavirin/800 mg boceprevir], but response is dependent on residual interferon responsiveness." They added that, "Treatment failures to [pegylated interferon/ribavirin] with > 2 log10 viral drop at [week 12] may be good candidates" for triple therapy.
In a related study, researchers looked at response to boceprevir combination therapy in 357 "null responders" with genotype 1 HCV who had less than a 2 log10 drop in HCV RNA after 12 weeks of prior treatment with pegylated interferon/ribavirin, or failure to achieve undetectable viral load if treated longer than 12 weeks.
Participants received 1.5 mcg/kg/week pegylated interferon (PegIntron) plus boceprevir at doses of 100, 200, 400, or 800 mg, some with ribavirin. The control arm received standard therapy, adding boceprevir if HCV remained detectable. Early data showed that the lower doses of boceprevir were less effective, so all patients who demonstrated virological response to boceprevir switched to triple combination therapy using 800 mg boceprevir for an additional 24 weeks.
SVR rates ranged from 2% in the control group to 14% using the boceprevir regimens studied, though no patients received triple therapy with the highest dose of boceprevir for the full treatment period. Individuals who experienced a viral load decrease greater than 2 log10 at week 12 were most likely to achieve undetectable HCV RNA on triple therapy. Boceprevir resistance mutations were detected in a majority of subjects who did not achieve SVR.
The investigators concluded that, "Some 'null' responders to [pegylated interferon/ribavirin] can achieve an SVR with [pegylated interferon/ribavirin/800 mg boceprevir], but response is dependent on residual interferon responsiveness." They added that, "Treatment failures to [pegylated interferon/ribavirin] with > 2 log10 viral drop at [week 12] may be good candidates" for triple therapy.
Looks like lots of riba works well too with the BOC
"Interim results also demonstrate that full dose ribavirin is optimal."
"Interim results also demonstrate that full dose ribavirin is optimal."
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