Aa
Digested the AASLD news, I am bummed too
Hepatitis researcher wrote in a previous post:
"Not only would Protease +SOC for clear nonresponders not permanently eliminate the virus but something much worse will likely happen ( to quote as mremeet has properly pointed out some hundred posts ago: " you will be saddled forever with resistance mutations against this treatment component").: This archived resistance mutations against telaprevir would make it impossible to clear the virus at that important future moment when finally the next chance to treat with an inhibitor combo like Protease + Polymerase +maybe Nitazoxanide will become available that MIGHT, JUST MIGHT give a decent percentage chance to clear despite the preexisting IFN resistance. These are one way roads, just like you cannot normally shake interferon resistance, you cannot shake off specific antiviral resistance, once it is established, EVEN IF A SEQUENCE TEST WILL SHOW THAT YOU HAVE RETURNED TO WILD TYPE AND NO MORE MUTATIONS CAN BE "FOUND".
So this is the first authoritative confirmation of what we suspected, ie. that telaprevir could be a one-time shot because of being left with drug resistance. Not only that, but any other drug with the same resistance profile is off the menu once specific antiviral resistance is established. Might that mean any other ns3 PI?
I was in a Prove2 no-riba arm, failed tx with a breakout and now have VX-resistant mutations. I was just coming to terms with failing tx. Now I've got to get my head round waiting for some other drug beyond VX that can kill those mutations. When I did the trial I knew that the tx could fail but I didn't bargain on f***ing up my future chances of a cure for years to come because of it. That was definitely not explained and if it had been I wouldn't have done it.
Well, too late to whine about it now, but I am really pissed and I want to highlight for others entering a trial what the consequences might be.
dointime
"Not only would Protease +SOC for clear nonresponders not permanently eliminate the virus but something much worse will likely happen ( to quote as mremeet has properly pointed out some hundred posts ago: " you will be saddled forever with resistance mutations against this treatment component").: This archived resistance mutations against telaprevir would make it impossible to clear the virus at that important future moment when finally the next chance to treat with an inhibitor combo like Protease + Polymerase +maybe Nitazoxanide will become available that MIGHT, JUST MIGHT give a decent percentage chance to clear despite the preexisting IFN resistance. These are one way roads, just like you cannot normally shake interferon resistance, you cannot shake off specific antiviral resistance, once it is established, EVEN IF A SEQUENCE TEST WILL SHOW THAT YOU HAVE RETURNED TO WILD TYPE AND NO MORE MUTATIONS CAN BE "FOUND".
So this is the first authoritative confirmation of what we suspected, ie. that telaprevir could be a one-time shot because of being left with drug resistance. Not only that, but any other drug with the same resistance profile is off the menu once specific antiviral resistance is established. Might that mean any other ns3 PI?
I was in a Prove2 no-riba arm, failed tx with a breakout and now have VX-resistant mutations. I was just coming to terms with failing tx. Now I've got to get my head round waiting for some other drug beyond VX that can kill those mutations. When I did the trial I knew that the tx could fail but I didn't bargain on f***ing up my future chances of a cure for years to come because of it. That was definitely not explained and if it had been I wouldn't have done it.
Well, too late to whine about it now, but I am really pissed and I want to highlight for others entering a trial what the consequences might be.
dointime
My thoughts are with you. I can see you are having a difficult time.
Zazza
Zazza
Be gentle with me fellows...I'm having a very rough day.
No...I started DD at 26 weeks..@ 10 -11 weeks upped riba from 1000 to 1400mg. I Have asked to stop tx....Hep Dr. (Director of Hep. Dept at a University Hosp) says...he cannot advise that at this time....
Have you gotten another opinion on your treatment? I forgot your stats, but I believe most stop at week 24 if still detectible unless you're treating only to improve liver condition as opposed to having reasonable odds of SVR. Also, never heard of anyone double dosing that long.
-- Jim
-- Jim
Did you say you've been double dosing for 35 weeks and you still have viral load of 1350?
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