Aa
Excerpt regarding cirrhosis
Released:5/7/2012 3:40 PM EDT
Source:University of California, San Diego Health Sciences
Research with mice reveals possible strategy to reverse fibrosis in liver and other organs
Hepatitis C Research and News
The following is an excerpt from the above link. I find it very exciting in that they seem to really have a handle on reversing fibrosis.
Newswise — An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.
The work is published in the May 7, 2012 online Early Edition of the Proceedings of the National Academy of Sciences.
“The take-away message is two-fold,” said David A. Brenner, MD, vice chancellor for Health Sciences, dean of the UC San Diego School of Medicine and senior author of the paper. “First, we’ve shown that liver fibrosis is markedly reversible and we now better understand how it happens. Second, we can start looking for ways to direct active myofibroblasts to stop producing scar, and become inactive. We can focus on developing drugs that promote cell change and regression. It raises the bar for prospective treatment tremendously.”
Source:University of California, San Diego Health Sciences
Research with mice reveals possible strategy to reverse fibrosis in liver and other organs
Hepatitis C Research and News
The following is an excerpt from the above link. I find it very exciting in that they seem to really have a handle on reversing fibrosis.
Newswise — An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.
The work is published in the May 7, 2012 online Early Edition of the Proceedings of the National Academy of Sciences.
“The take-away message is two-fold,” said David A. Brenner, MD, vice chancellor for Health Sciences, dean of the UC San Diego School of Medicine and senior author of the paper. “First, we’ve shown that liver fibrosis is markedly reversible and we now better understand how it happens. Second, we can start looking for ways to direct active myofibroblasts to stop producing scar, and become inactive. We can focus on developing drugs that promote cell change and regression. It raises the bar for prospective treatment tremendously.”
Sometimes I guess, it doesn't suck to be a mouse ;)
"We can focus on developing drugs that promote cell change and regression. It raises the bar for prospective treatment tremendously.”
Thank you very great article...look at how they may have come up with an HIV vaccine out of one of their meds, just goes to show how big pharma is complainned about - but oh so essential. Good news coming all the time. GREAT.
"We can focus on developing drugs that promote cell change and regression. It raises the bar for prospective treatment tremendously.”
Thank you very great article...look at how they may have come up with an HIV vaccine out of one of their meds, just goes to show how big pharma is complainned about - but oh so essential. Good news coming all the time. GREAT.
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