Some people also experience symptoms before starting tx. I had most of these off and on for about a year before start tx. That is why I didn't want to wait to start getting rid of this rotten virus. Now that I'm doing tx, I have lots of these too, but strangely my joint pains have gone away... replaced with bone pains... and some other things have altered. I just keep reminding myself that once I get through with tx and gets these drugs out of my system I'm going to feel better than I have in many years so it is worth it.