I relapsed on SOVALDI and Ribavirin

[billewingad]

I have Hep-C G2.
Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million),
within 4 weeks into treatment my Hep C virus was undetectable.
12 weeks end of treatment my Hep C virus was undetectable.
4 weeks after treatment my Hep C virus was undetected.
12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed.

What are my chances of a cure now?

[nan535]

interesting article. I'm curious how many of the doctors who are now treating patients with steatosis with these new meds are aware of this.  I personlly have had the feeling that the real trials are going on now and the doctors are learning as they go along. My husband has commented to me that at times he feels like a guinea pig. I guess with anything new there will always be trial and error as part of the learning process.

Nan

[billewingad]

BIG thanks Dave.

[klonny55]

I think part of the reason for the focus on genotype 1 is because it is by far the most prevalent variant in the US. About a year ago I was looking for clinical trials using new meds to participate in and the only I could find accepting genotype 2s was the phase 2 trial with GS-5816.

I think that since the 12 week sofosbuvir/ribavirin trial data for genotype 2s was so strong that it was felt that there no need to go further. I could well be that ledipasvir and other new meds will work for genotype 2 but it has not been tested yet since the trials were not accepting genotype 2s. This is just my theory, not necessarily a statement of fact.

Also I found the following article published just last month about the correlation between steatosis (fatty liver) and SVR prospects. Your steatosis may well be a contributor to your relapse.

http://www.wjgnet.com/1007-9327/full/v20/i23/7089.htm

It sounds like you are in good health without much liver damage so I feel confident you SVR day will come in the not to distant future. All the best, Dave

[ms maddie]

I think the trials only involved GT 1 and that is why approval, if granted, would be for GT 1 only.

[billewingad]

I don't under stand why G1 only. G1 is the hardest to treat, so it seem to me a new treatment that is stronge enough to treat G1  would be effective on other Genotypes that are eazier to treat like G2.

[billewingad]

I don't under stand why G1 only. G1 is the hardest to treat, so it seem to me a new treatment that is stronge enough to treat G1  would be effective on Genotype that eazier to treat like G2.