Incivek radioactive?

[Naya888]

Hello everybody Thanks for  your support ,especially earlier this Tx I will be able to  get over this triple Tx now.1 more week to go then switching to new MD Thanks God.Did anybody heard about Incivek having radioactive components in it?Pls let me know

[Naya888]

Thank you for this usefull clarification

[willbb]

The above poster is correct.The carbon was used to track half-life and elimination times.

There is no dangerous component.

Good luck with your treatment..
Will

[thatoldhobo]

I believe the 14-c referred to in the study is an added radioactive substance to allow tracking of the elimination. I would highly doubt the actual meds themselves are radioactive. There are better things to worry about, don't stress yourself. good luck.

[willbb]

Hi..

Elimination
Following administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and 1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and 18.8%, respectively. After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%. The mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the effective half-life is about 9 to 11 hours.

http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201917lbl.pdf