Thanks Will. I'll ask Dr Thursday. I feel it's the diuretics. I never have them when I'm off of them. I finally got into a "normal" sleep routine and this isn't helping. I can go to bed by 9:30, take RIBA at 3 n go back to sleep til time for work at 5:45. Someone here suggested earlier RIBA. Tryimg to function on no sleep catches up w you after a few months.
Things that make ya go hmmmm in the night.
Zoney, Karen :)
Hmmmm try Gatorade, if Canada Dry was the answer it would be on the sidelines of sporting events.
Good idea to get potassium checked if experiencing cramping as low level is a known cause
Also be mindful of too much quinine ..especially with low platlets:
Will
Changes in platelet function and reactivity induced by quinine in relation to quinine (drug) induced immune thrombocytopenia.
Connellan JM, Deacon S, Thurlow PJ.
Department of Haematology, Austin Hospital, Heidelberg, Victoria, Australia.
Abstract
Quinine, a drug known to induce immune mediated thrombocytopenia, has been postulated to mediate binding of drug dependent antibodies to a range of platelet membrane glycoproteins. Quinine may not act solely as a hapten however, as we have shown that it inhibits platelet aggregation (ex vivo and in vitro) and release and modifies the ability of activated platelets to bind the adhesive proteins fibrinogen and fibronectin in a dose dependent fashion. Studies on the effect of quinine on the binding of monoclonal antibodies HuPlml (GpIIIa) FMC25 (GpIX) and AN51 (GpIb) to platelets shows a selective reduction in AN51 binding. In addition quinine induced platelet antibodies from thrombocytopenic patients, in the presence of quinine, have been shown to inhibit binding of these monoclonal antibodies to platelets to varying degrees. These observations suggest that quinine causes widespread but specific conformational changes in platelet membrane antigens which may expose neoantigens resulting in the production of quinine induced antibodies.
PMID: 2028452 [PubMed - indexed for MEDLINE]"
Thank You !!
I will be giving this a try . I have been getting leg and foot cramps throughout treatment, just come out of nowhere