Low Neutrophils

[Diana66]

Since I started tx with a base of 1.64 I have been flaoting around the 0.56-0.7-0.88-1.05 for the last 14 weeks

Today all of a sudden I bottomed to 0.3. This is on an already reduced Interferon dose of 135. I am waiting to hear from the doctor now of what the plan is but would this sudden drop be just from the Interferon or is it possible to have other reason as well

2 weeks after the Incivek: Hemoglobin at 10.1, Platelets at 58 so only the Neutrophils are the problem

Any ideas, suggestions?

[Idyllic]

I have four shots of Neupogen I would send you if possible. I realize you don't know me from Adam (or is that Atom) ...plus I doubt they would make it around the world at the right temperature. I hope you are seeing we are just frustrated on your behalf. I know you have read and researched all this and you are very well informed so you are likely already aware of much of what has been said already.

This was in a 'missed Peg dose" post last month
http://www.medhelp.org/user_photos/show/369543?personal_page_id=1282072

Like Can-do points out much of these guidelines are based on combination therapy. You are breaking new ground.

[can-do-man]

Lets not forget them "guidelines" were made when it was just SOC, and we had a 38% cure rate for geno 1's and that would have been less if it wasn't for the "good" doctors who paid no attention to those...

[Diana66]

Unfortunately it is not my choice. There is not much I can do, someone needs to prescribe the neupogen and at the moment they don't :(

So 17 have relapsed with dose reduction. Out of how many?

Jules, I do not have a choice here unfortunately

[Idyllic]

I can imagine how frustrating this must be right now. I really hope the timing of all this works out and your ANC rebounds enough for you to continue treatment.

I am not sure what you can do since you are right. It is the weekend and on most of the guidelines it does indicate to discontinue PegIFN until resolution when ANC < 0.50.

It's as flcyclist said in his post as well as in this chart
http://www.medhelp.org/user_photos/show/368377?personal_page_id=1282072
________________
The table as well as others are:
http://www.hepatitis.va.gov/provider/guidelines/2012HCV-tables.asp


Hang in there!

[Dee1956]

I hope your numbers are back up on Monday so you can take your shot. or hopefully on Monday they will give you Neupogen.
Since you are already on a reduced dose I would worry about skipping a week.
Saying that your doctor knows your entire story/history so he/she knows what is best for you

I hope the best for you.  My ANC dropped below the 500 several times during my first tx and nothing was done about it.  At the time I did not know anything about it.  It stayed low for a long time after tx, still they did nothing.  I was on INF, RIBA and a polymerase inhibitor (trial drug)

Good luck
Dee

[flcyclist]

http://www.gene.com/download/pdf/pegasys_prescribing.pdf

Tabe 3, pg 5.