COULD ALL THAT COMPLETED TREATMENT WITH SOVALDI & OLYSIO SHARE YOUR EXPERIENCE ?

[FRED220]

I would like to see all that finish this treatment to take a moment to encourage us that are starting now. Please share with us your stories and CONGRATULATIONS TO ALL!  

[nan535]

Glen/Mark
Your last two posts seem to provide some support for Dr Kwo's decision (see other thread  http://www.medhelp.org/posts/Hepatitis-C/Why-SovaldiOlysio-at-this-point/show/2240181)  to treat GT 1a patients (who are treating with Sovaldi + Olysio) with Ribavirin.
Although Mark had to reduce his dose of ribavirin he was able to reach SVR
neverthless.  Unfortunately Glen, you were unable to reach SVR without the ribavirin. There may have been other reasons but that one kind of jumped out at me.

Nan

[NYCMark]

Hi Fred
I completed my Tx about April 7. I took 12 weeks of Sovaldi Olysio + ribavirin. My 12 week EOT test July 8 was Not Detected.  I still have to go for the 24 week EOT test in October. So far, so good!
I am GT 1a, and had been treated many times before with various combinations of interferon and ribavirin, always with relapse.  On this last treatment, I did have to reduce my dose of riba (from 1000 to 600) because of dropping hemoglobin (and fatigue), and I showed some abnormal blood tests (elevated bilirubin).  Otherwise, mild side effects.  Quite back to normal now.
Good luck!
Mark

[GP7852]

Undetected at 4 weeks on S&O.Still undetected at the finish(12 weeks) At 1 month post treatment relapsed.The lady who does my bloodwork said she had 2 other relapses from S&O the previous day.I did not ask if they were geno 1a stage 4 cirrhosis like I am but it seems that the relapsers are the geno 1a's.
                  Good luck Fred    Glen

[48weeks]

For treatment naive the success rate for S+O are awesome, but I have a lot going against me as I said before. Not sure what your situation is. Some people are having tremendous success with that treatment.

[FRED220]

60 % cure rate ? i have read lots and have not seen numbers that low, I am thinking maybe 80 % or higher. I go to  UM  hospital and they are very happy with the results they are getting but wont say anything else. I think it will be very sad to see numbers that low after so much has been said about over 90% SVR. I will pray and hope for the best for everyone.  

[Sovaldi13Newbie]

I'd ask the same question, these new drugs are coming out in November right, with a higher rate of SVR than 60%? They are just tweaking these meds, who does better with what and how long type of thing, to my mind. They are so new. Best of luck to everyone!

[Sovaldi13Newbie]

Hi Fred: I was one of the seemingly few who did experience sides on Sovali Olysio, but that could be because I am extremely drug sensitive (went through rounds of chemo and a bone marrow transplant and only used a little bit of Tylenol for pain because I hate the way drugs are so hard on me, pain meds, etc) And I had those issues so I'm still on a bit of immune suppression.

And the sides seem to settle down once my body got more used to the drugs. But it was anxiety (that fades away after a few hours of taking it and I used a small amount of klonopin to help me through that, so glad I don't have to take that now that I'm off the treatment) fatigue, muscle aches, insomnia (but I really think my insomnia was partly because I took my drugs later than other people, I took mine at 2 or 3 pm. So I could get work done in the morning. Headaches but they went away int he last month or so.

But like I said, I think I'm a pretty rare case because of all my issues, and I might be older than you I'm 60. Most I've read about say their sides were negligible and even with me, I found this to be completely doable, I could do it again if I have to in another formulation, etc.

Geno Type 1b, treatment naive, was 3,000,000 at start undetectable at around the 3rd week, liver function tests went from averaging 50 60 to in the teens, low 20s. Just finished two days ago. Will do a viral load at week 4. Hoping for the best. I think the time doesn't matter as long as you do the same time every day. At least that what my doc said. Best of luck!!! To me, completely doable!

[48weeks]

Fred, I just posted this in another thread. What are your specifics. I think we are starting to see some results coming back now from this treatment, and some of them aren't great.  Here is my post.

I think I've complained about my Gastroenterologist on here before. He seems to be a tad out of the loop. I just saw him and he is suggesting I go on Sovaldi/Olysio where he is saying I have a 60% chance of SVR. Why would I do that since Sovaldi+Ledipasvir is supposed to be out this Fall/Winter with significantly higher success rates. I am a GT 1a, IL28B=TT, Non responder to Interferion treatments 3 times, and Relapsed 6 months after EOT of Telapervir+Int+Rib, Liver Biopsy stage 2-3. So glad I'm on this blog, I feel like I know more than my Doc about my disease sometimes. I just want him to get me on S+L when it's available, and then maybe make a move if that doesn't work out.  Anybody have anythoughts?

[FRED220]

Congrats!  I am hoping I  dont get much side effects since I do have to go to work   Did you take your meds in the morning or in the evening?

[candyce1953]

I did 12 weeks Sovaldi an olysio
All undetected thru treatment
And also 4+8 weeks after
Will be doing final end of treatment 12 labs in 2 weeks
Then I will know for sure

Main side effect for me extreme exhaustion( but I also have auto immune disease)

Was 1B, had it 43 years , 2/3 stage

[pat12]

Hi Fred, my husband is GT1b, cirrhosis, treatment naïve, was undetected at EOT+4 weeks, just the other day.  No symptoms to speak of.  Waiting for September and hoping for SVR12...  Good post by the way....

[flyinlynn]

Hi Fred

Good luck on your treatment.

I am a GT 1a 3 time null responder to interferon and interferon wirh ribavirin with cirrhosis diagnosed in 2008  Child A MELD 7.

I treated with Sovaldi Olysio from 3/19 to 6/10 the virus showed undetectable at 4 weeks and at EOT. Didn't really experience much in the way of side effects just maybe some mild headaches but who knows if that was the meds or just me.

Waiting to see if I am still undetectable 12 weeks post treatment on 9/2.

That's about it waiting and hoping for SVR

Again good luck
Lynn