Aa
Milk Thistle benefits
http://www.hepatitis-central.com/mt/archives/2008/08/hep_c_quality_o.html
FYI....This link from Hepatitis C Central explains the advantages of taking Milk Thistle for anyone with Hep C, including taking it during treatment. I just wanted to pass this on if any of you are currently NOT taking this supplement. I have been taking this for years and am convinced that it has helped me.
I hope this helps someone out there!
FYI....This link from Hepatitis C Central explains the advantages of taking Milk Thistle for anyone with Hep C, including taking it during treatment. I just wanted to pass this on if any of you are currently NOT taking this supplement. I have been taking this for years and am convinced that it has helped me.
I hope this helps someone out there!
but you can get it in the usa - although the benefits are greater with injectable - oral still works and its relatively inexpensive
i read your post - sounds like an endorsment to me ---" Silymarin and its efficacy for NASH ,primary biliary cirrhosis, autoimmune hepatitis , akute viral hepatitis, Hep B , Hep C , mega dosis of Silymarin orally , Silibin IV (legalon-sil) for Hep C and as rescue therapy for slow or non responders as well as Silibin IVs as a lead in for SOC and prevention therapy of reinfection after transplant."
there are many trials ongoing with it - there are many other conditions not mentioned in your post like diabetes and iron overload that respond to its use --- so its good for you - it doesnt hinder tx but actually helps it - and theres no known proof showing not to take it during tx - just because a dr doesnt recommend it means nothing to anybody but him - some say no to it because of overtaxing the liver - ha - then they turn around and start prescribing all kinds of meds for sides complications etc
i read your post - sounds like an endorsment to me ---" Silymarin and its efficacy for NASH ,primary biliary cirrhosis, autoimmune hepatitis , akute viral hepatitis, Hep B , Hep C , mega dosis of Silymarin orally , Silibin IV (legalon-sil) for Hep C and as rescue therapy for slow or non responders as well as Silibin IVs as a lead in for SOC and prevention therapy of reinfection after transplant."
there are many trials ongoing with it - there are many other conditions not mentioned in your post like diabetes and iron overload that respond to its use --- so its good for you - it doesnt hinder tx but actually helps it - and theres no known proof showing not to take it during tx - just because a dr doesnt recommend it means nothing to anybody but him - some say no to it because of overtaxing the liver - ha - then they turn around and start prescribing all kinds of meds for sides complications etc
Old news !
Read my post above Silibin IVs are only approved in Austia in combination with SOC
for proven previous non responders , require several weeks of clinic stay , many hrs of IV per day
and are very expensive.
b
Read my post above Silibin IVs are only approved in Austia in combination with SOC
for proven previous non responders , require several weeks of clinic stay , many hrs of IV per day
and are very expensive.
b
1. alt levels mean nothing
2.they didnt dose high enough in halt c - dont base opinions on 1 study - like anything else
3.read coerics links
4. nevermind ill do it 4 u
5.Legalon-SIL downregulates HCV RNA as well as HCV core and NS5A proteins in CON1 cells
from Jules: many studies in the past few years conducted by Peter Ferenci have shown IV silibin to have significant antiviral efficacy against HCV (see link below). So for patients who are peg/rbv nonresponders and for that matter responders as well IV silibin should be researched in combination with telaprevir and boceprevir as it might have a particular benefit for prior null responders and partial responders and perhaps most importantly for patients who are contraindicated for peg/rbv but could combine IV silibin with an HCV protease.
LS downregulated HCV RNA (core region) in a dose-dependent and also a time-dependent manner in CON1 cells. The HCV RNA (core region) level was decreased 21% following 6 h treatment with LS 200 μmol/L compared with the DMSO control (P < 0.05, Figure Figure2A).2A). HCV RNA (core region) levels were further decreased after 24 h treatment by both LS 50 μmol/L (55% decrease, P < 0.05) and 200 μmol/L (88% decrease, P < 0.01) when compared with vehicle (DMSO) control (Figure (Figure2A).2A). The HCV RNA (NS5A region) level was also decreased 43% following 6 h treatment with LS 200 μmol/L compared with DMSO control (P < 0.01 Figure Figure2B),2B), and was also further decreased after 24 h treatment by both LS 50 μmol/L (62% decrease, P < 0.01) and 200 μmol/L (87% decrease, P < 0.01) (Figure (Figure2B).2B). LS 200 μmol/L also downregulated HCV core (by 57%) and NS5A protein (by 49%) after 24 h of treatment although this was statistically significant only for HCV core protein, P < 0.05). This effect was more pronounced following 48 h of treatment: LS 200 μmol/L decreased HCV NS5A protein expression by 65% (P < 0.05), while LS significantly decreased HCV core protein expression in a dose-dependent manner (52% reduction at 50 μmol/L and 85% reduction at 200 μmol/L P < 0.01) (Figure (Figure33).
2.they didnt dose high enough in halt c - dont base opinions on 1 study - like anything else
3.read coerics links
4. nevermind ill do it 4 u
5.Legalon-SIL downregulates HCV RNA as well as HCV core and NS5A proteins in CON1 cells
from Jules: many studies in the past few years conducted by Peter Ferenci have shown IV silibin to have significant antiviral efficacy against HCV (see link below). So for patients who are peg/rbv nonresponders and for that matter responders as well IV silibin should be researched in combination with telaprevir and boceprevir as it might have a particular benefit for prior null responders and partial responders and perhaps most importantly for patients who are contraindicated for peg/rbv but could combine IV silibin with an HCV protease.
LS downregulated HCV RNA (core region) in a dose-dependent and also a time-dependent manner in CON1 cells. The HCV RNA (core region) level was decreased 21% following 6 h treatment with LS 200 μmol/L compared with the DMSO control (P < 0.05, Figure Figure2A).2A). HCV RNA (core region) levels were further decreased after 24 h treatment by both LS 50 μmol/L (55% decrease, P < 0.05) and 200 μmol/L (88% decrease, P < 0.01) when compared with vehicle (DMSO) control (Figure (Figure2A).2A). The HCV RNA (NS5A region) level was also decreased 43% following 6 h treatment with LS 200 μmol/L compared with DMSO control (P < 0.01 Figure Figure2B),2B), and was also further decreased after 24 h treatment by both LS 50 μmol/L (62% decrease, P < 0.01) and 200 μmol/L (87% decrease, P < 0.01) (Figure (Figure2B).2B). LS 200 μmol/L also downregulated HCV core (by 57%) and NS5A protein (by 49%) after 24 h of treatment although this was statistically significant only for HCV core protein, P < 0.05). This effect was more pronounced following 48 h of treatment: LS 200 μmol/L decreased HCV NS5A protein expression by 65% (P < 0.05), while LS significantly decreased HCV core protein expression in a dose-dependent manner (52% reduction at 50 μmol/L and 85% reduction at 200 μmol/L P < 0.01) (Figure (Figure33).
Rest assured I am very much aware of the latest research on Silymarin taken orally
or by IV as Legalon-Sil. Most of those studies take place in Europe and I get quaterly
updates. As a matter of fact this year`s March issue of the German Liver Magazine
"Lebenszeichen" (sign of life) has 3 big double page spreads about Silymarin and its
efficacy for NASH ,primary biliary cirrhosis, autoimmune hepatitis , akute viral hepatitis,
Hep B , Hep C , mega dosis of Silymarin orally , Silibin IV (legalon-sil) for Hep C and as
rescue therapy for slow or non responders as well as Silibin IVs as a lead in for
SOC and prevention therapy of reinfection after transplant.
b
or by IV as Legalon-Sil. Most of those studies take place in Europe and I get quaterly
updates. As a matter of fact this year`s March issue of the German Liver Magazine
"Lebenszeichen" (sign of life) has 3 big double page spreads about Silymarin and its
efficacy for NASH ,primary biliary cirrhosis, autoimmune hepatitis , akute viral hepatitis,
Hep B , Hep C , mega dosis of Silymarin orally , Silibin IV (legalon-sil) for Hep C and as
rescue therapy for slow or non responders as well as Silibin IVs as a lead in for
SOC and prevention therapy of reinfection after transplant.
b
It does NOT have an effect on VL, and it does NOT help liver enzymes. The article says that.
I'm sure the "people who ate bad mushrooms" forum would appreciate your information. But as far as killing the HCV virus it does nothing. If people think it does them good go for it. My only point is the HALT-C article by Cutler the OP posted states
1. No beneficial effect of silymarin was found on ALT levels (serum alanine aminotransferases) – an enzyme often elevated with liver injury.
2. No beneficial effect of silymarin was found on Hepatitis C virus RNA levels.
I'm sure the "people who ate bad mushrooms" forum would appreciate your information. But as far as killing the HCV virus it does nothing. If people think it does them good go for it. My only point is the HALT-C article by Cutler the OP posted states
1. No beneficial effect of silymarin was found on ALT levels (serum alanine aminotransferases) – an enzyme often elevated with liver injury.
2. No beneficial effect of silymarin was found on Hepatitis C virus RNA levels.
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