Pharmasset

[nazzareno]

I don't understand why Pharmasset is being so adored right now, especially by the market. From what I've read most of their trials have been very positive but also very small. I hope their meds are as good as the market makes it appear. Anyone know more?

[curiouslady1]

Just a footnote to this thread as I had mentioned in another.  I was informed today that all six participants at our site in this BMS/Pharmasset all oral experimental trial had RVR and I know of two others in other states as well for a total of 8 that I know of achieving RVR.  The energy that attagrl speaks of is not idiosyncratic to her either.  I have posted several times about feeling much better in just a short period of time.  It appears those undergoing studies with the oral drugs in combo with the SOC (trials done at an earlier point in time have a very high percentage of SVR . . . something over 90% and up to 100% which is already a better finding than what is on the market now. . . check web sites in my journals).   Those of us in the all oral trials will have to wait a while longer before we can proclaim that good news of SVR interferon free.    

[attagrl]

Thought I'd jump in since I'm also in the same trial as curious and gonnab. I'm 35, started with a viral load around 3.7million, and was undetected by my week 3 visit; just got my week 6 results yesterday and still undetected! The first week or two I had some significant fatigue and headaches, but since then I've experienced ZERO side effects and am even training for a half-marathon in two weeks. I also do karate and I won my sparring division last weekend at a big tournament, so kicking some literal butt along with HCV's. ;)

I feel blessed to be a part of this exciting study and even more, my mom is also a participant and is undetected as well!

[curiouslady1]

Actually, there are several people that are members of medhelp forum on all oral medication trials which involve meds put out by Pharmasset.  Not all of them are posting to the list and some want to maintain their privacy I believe.  The people that I know are all doing very well but it is too early for anyone to say that their undetectable status has been sustained for 6 months following treatment.  You are correct that this is a leap of faith that we have all made.  For myself, the alternative was far worse than either staying infected or getting into a trial with drugs I felt comfortable with.  FYI I am 64, 40 year infection, was high VL.  You may want to check people's journals and notes and prior posts and get a sense of the site and the information on it.    

[UKgirl55]

Love your screen name! What great news from you AND curiouslady. I'll be watching and waiting with baited breath! I could have been on this trial TWICE, but I was unsure! Sometimes you really need to take a leap of faith!

[UKgirl55]

Thank you for your reply. I didn't realize that interferon sparing was the same as all orals. I may have the chance of going on the new two PSI's. I saw that the four arms were something like...PSI 7977+PSI 938, PSI 7977+Riba, PSI 7477+PSI 938+Riba and of course the PSI 938 (monotherapy). I'm so happy to finally hear from those that are on the all orals. I was screened for the Gilead GS (four orals), but backed out after I heard about the GS-9190 problem. I'm now glad I did! I'm geno 1a, very high VL, treatment naive. 56 years old...SO ready to do something, but know how drug sensitive I am, so have been terrified to do the interferon.

[gonnabhepcfree]

www.clinicaltrials.gov plug in NCT01435044 that number is for the Quantum study and they are recruiting in Austin Texas although they might not have actually started yet.