I hold to the full riba concept. There have been studies relating reduced riba to potential relapse. I'd try to get back to full riba dose and if you can hold hgb up, then I'd see about reducing the procrit frequency. My doctor was okay with reducing the peg (and I was reduced for about 2/3 of my TX) but adamant about staying at full riba.
I believe your husband is treating for 72 weeks.
Therefore, I would increase Riba to 1200 mg. and watch HGB closely. Hit this thing with everything you've got Eureka.
I'm rooting for you...
I would also consider the quality of life issues here. Not sure why your husband needs to do anything differently than he is now. Can't he just enjoy a higher hgb level for his remainder of tx? I seriously doubt that increasing riba back up at this point would have any impact on his odds of SVR.
"I seriously doubt that increasing riba back up at this point would have any impact on his odds of SVR. "
I disagree. He's at Week 54 out of 72 and went UND at 13 weeks. I think, especially in light of what Mike posted, the rule of thumb of 100% of the drugs 100% of the time as much as possible, the impact of relapse here considering his advanced stage and what it would mean to retreat, I would want to hammer it, if it were me, as long as it's tolerated and not risking overall health.
If quality of life is so compromised that it threatens adherence to treatment, that's a consideration. If I'm going to compromise one or the other, it's going to be quality of life for awhile - I say that while recognizing it is an entirely personal decision and that is my opinion only.
Trish
Can't he just enjoy a higher hgb level for his remainder of tx? "
Something about black box warnings over having epogen have you go up and over 12 is important althought I can't remember exactly what it is.....epo is a dangerous drug - even though it is an absolute miracle worker you have to be VERY careful how high your hemo goes.
I agree with not dose reducing to get SVR but as well doctors are pretty leery of epo just cause of that reason.
" I think, especially in light of what Mike posted, the rule of thumb of 100% of the drugs 100% of the time as much as possible"
I agree with this I"ve never understood the 80/80/80 because it almost makes you feel like you can screw up and miss a couple and not have it matter.....like a permission or something It is CRUCIAL to bev 100% compliant to beat this crappy disease (as best as anyone can be compliant anyway)
Well, the 80/80/80 rule was the MINIMUM - preference is 100/100.