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SOCS3 Gene: Insulin Resistance, IFN resistance
For six years, I believed there was a single-source connection between interferon resistance and interferon resistance. It is, as I suspected, a gene. The gene is SOCS3 - Suppressor Of Cytokine Signaling-3. The discovery of this gene also sheds some light on why prior nonresponders have more trouble acheiving SVR.
1. SOCS-3 is elevated by HCV's core protein.
2. SOCS-3 elevation causes interferon resistance.
3. SOCS-3 elevation causes insulin resistance in the liver.
4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.
5. SOCS-3 is further elevated in people who have treated unsuccessfully.
These findings suggest a new and viable target for therapy.
1. SOCS-3 is elevated by HCV's core protein.
2. SOCS-3 elevation causes interferon resistance.
3. SOCS-3 elevation causes insulin resistance in the liver.
4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.
5. SOCS-3 is further elevated in people who have treated unsuccessfully.
These findings suggest a new and viable target for therapy.
It didnt work so i didnt finish the pack, but it did give me a sweet tooth.
So yeh i'd say it raised enzymes
CS
So yeh i'd say it raised enzymes
CS
"I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?"
There have been several cases of elevated liver enzymes caused by it.
Co
There have been several cases of elevated liver enzymes caused by it.
Co
So you guys think that because my liver started healing itself - it stopped producing SUGAR.. SUGAR.. Sugar.
And the sugar is melting offa my hipsters?
Hmmm..
LMAO!
That's kinda funny.
And the sugar is melting offa my hipsters?
Hmmm..
LMAO!
That's kinda funny.
"Knowing more about each individual as an individual instead of lumping all together"
You said it best.
Co
You said it best.
Co
"think CO would advise obese patients to try and lose weight."
You know me well. :) Besides teaching them about IR, I put them in my nutrition class.
"Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone"
And it may also aid weight loss.
Using insulin sensitizers worked for co-infected patients and non-responders. Give me your honest opinion. Do you think weight loss/diet would give them a 71% EVR?
It isn't that I believe that people are lazy or not determined to loose weight.....it's that some of them just can't.
People are willing to double dose and face whatever risk for a chance at less than 71%. Now there's a new option.....and I'm really excited.
Co
You know me well. :) Besides teaching them about IR, I put them in my nutrition class.
"Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone"
And it may also aid weight loss.
Using insulin sensitizers worked for co-infected patients and non-responders. Give me your honest opinion. Do you think weight loss/diet would give them a 71% EVR?
It isn't that I believe that people are lazy or not determined to loose weight.....it's that some of them just can't.
People are willing to double dose and face whatever risk for a chance at less than 71%. Now there's a new option.....and I'm really excited.
Co
Thank you for a very interesting read which has very much to do with me and many others that are pre tx in considering what they will be speaking to their Doctors about
I for one would not have known I was IR if it was not for CO thank you a million times
Knowing more about each individual as an individual instead of lumping all together for the same SOC is surely an advantage for SVR but taking it one step further with more studies can also prevent some sx that are miserable for people always I hear every one is different but yet they are not treated differently before tx all have the same tests going in most concerned with Viral Load and Genotype but very little else is looked at
in relation to an indivduals symptoms that brought them to the doctor in the first place
one could have many other factors besides HCV that need to be addressed before Tx I would assume if this was SOC then maybe the patient would not have to have so many uncomfortable sx in tx just a thought
Genetics would play a very important role
Lifestyle right up there with Genetics
Other conditions such as IR Fibromyalgia Lupus Arthritis and any other pre exsiting disorders which with todays population and current lifestyle of todays population
I would think Males and Females would also have different issues as well
All very interesting to say the least Since these conditions are not considered in most cases and there is a rush to tx It would seem in trials they would make is SOC
The main objective not to sell drugs but the ultimate goal of SOC
The smoking issue little to be found but since I smoke and am Insulin resistant there are many studies done on it I just typed in Insulin Resistance and Smoking and sure enough no one should smoke as they should not drink Alcohol prior to tx
Nor should any one be obese however the weight issue and smoking are two difficult issues for most people to control which is why I feel there is a real good need for pre treatment thorough dx and then tx just a thought
CS why did you say not to use Champix for quitting smoking I have used the patch the gum have not had any luck with the gum but have had luck with the patch in the past however with all the worry over this situation I am dieting good diet and starting with excercising 3 times a week and will increase Smoking is one thing very difficult for me
to stop at this time so anxed up about this HCV I find my self smoking more need an aid to quit diet has come easy the excercise not so easy but doing it
I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?
Still need a Fibroscan I am betting there is one here in Mexico so will look here if I do not hear back about one in LA all the best and I will keep asking questions
thanks again super thread
Baja
I for one would not have known I was IR if it was not for CO thank you a million times
Knowing more about each individual as an individual instead of lumping all together for the same SOC is surely an advantage for SVR but taking it one step further with more studies can also prevent some sx that are miserable for people always I hear every one is different but yet they are not treated differently before tx all have the same tests going in most concerned with Viral Load and Genotype but very little else is looked at
in relation to an indivduals symptoms that brought them to the doctor in the first place
one could have many other factors besides HCV that need to be addressed before Tx I would assume if this was SOC then maybe the patient would not have to have so many uncomfortable sx in tx just a thought
Genetics would play a very important role
Lifestyle right up there with Genetics
Other conditions such as IR Fibromyalgia Lupus Arthritis and any other pre exsiting disorders which with todays population and current lifestyle of todays population
I would think Males and Females would also have different issues as well
All very interesting to say the least Since these conditions are not considered in most cases and there is a rush to tx It would seem in trials they would make is SOC
The main objective not to sell drugs but the ultimate goal of SOC
The smoking issue little to be found but since I smoke and am Insulin resistant there are many studies done on it I just typed in Insulin Resistance and Smoking and sure enough no one should smoke as they should not drink Alcohol prior to tx
Nor should any one be obese however the weight issue and smoking are two difficult issues for most people to control which is why I feel there is a real good need for pre treatment thorough dx and then tx just a thought
CS why did you say not to use Champix for quitting smoking I have used the patch the gum have not had any luck with the gum but have had luck with the patch in the past however with all the worry over this situation I am dieting good diet and starting with excercising 3 times a week and will increase Smoking is one thing very difficult for me
to stop at this time so anxed up about this HCV I find my self smoking more need an aid to quit diet has come easy the excercise not so easy but doing it
I searched the Champix drug Varenicilina and it seems ok what was your take on it CS?
Still need a Fibroscan I am betting there is one here in Mexico so will look here if I do not hear back about one in LA all the best and I will keep asking questions
thanks again super thread
Baja
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