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Simeprevir deaths?
Have you all heard about the three deaths in Japan attributed to Simeprevir Sodium? Do you think this is the same as the Simeprevir (Olysio) here in the States?
"According to the Ministry of Health, Labor and Welfare, taking the drug will increase "bilirubin" by decomposing hemoglobin in the blood and may aggravate dysfunction of the liver and kidney."
http://www.globalpost.com/dispatch/news/kyodo-news-international/141024/3-die-after-being-administered-hepatitis-c-drug
"According to the Ministry of Health, Labor and Welfare, taking the drug will increase "bilirubin" by decomposing hemoglobin in the blood and may aggravate dysfunction of the liver and kidney."
http://www.globalpost.com/dispatch/news/kyodo-news-international/141024/3-die-after-being-administered-hepatitis-c-drug
Best Answer
If you look at the molecule models they are different, it's the only way I could tell, all the SOVRIAD (as it's called) info is in japanese
Good info there about the FDA
Yes they can only try their best. Especially as we keep cutting down their staffing.
The FDA has a huge mission if you think about it. Check new drugs. Invettigate both over the counter reported problems and well as prescription drugs to ensure medical consumer safety. Tylenol excedrin etc?
Also the have inspectors checking food processing facilites and having recalls of food products from salmonella concerns to products accidently contaminated with nuts and not labeled posing a danger to the allergic people out there. To I am sure humdreds of other problems.
So I have a great respect for those FDA workers out there but they are only human as well and there are only so many mant hours a day to get the missions they are tasked with done.
Just my thoughts
Lynn
Yes they can only try their best. Especially as we keep cutting down their staffing.
The FDA has a huge mission if you think about it. Check new drugs. Invettigate both over the counter reported problems and well as prescription drugs to ensure medical consumer safety. Tylenol excedrin etc?
Also the have inspectors checking food processing facilites and having recalls of food products from salmonella concerns to products accidently contaminated with nuts and not labeled posing a danger to the allergic people out there. To I am sure humdreds of other problems.
So I have a great respect for those FDA workers out there but they are only human as well and there are only so many mant hours a day to get the missions they are tasked with done.
Just my thoughts
Lynn
Hi
Your question to me
"In your search did run accross that eastern Asians require a different medication because thier body requires a different treatment of the same thing?"
My search was a farily simple on just Olysio Sovriad. The first hit is the jnj press release. I did not try to see about the different doses for Japan vs US and Canada but that is a curious thing indeed.
I dunno I am not a research scientist I guess. Just a blue collar kid.
Lynn
Your question to me
"In your search did run accross that eastern Asians require a different medication because thier body requires a different treatment of the same thing?"
My search was a farily simple on just Olysio Sovriad. The first hit is the jnj press release. I did not try to see about the different doses for Japan vs US and Canada but that is a curious thing indeed.
I dunno I am not a research scientist I guess. Just a blue collar kid.
Lynn
Just to chime in
I have had hep c probable since 1977 and was diagnosed with cirrhosis in Jan 2008. So my odds of HCC are about 20% every year.
Basically ever since I was DX with cirrhosis I have had new symptoms come around every year it seems.
So yeah hep c has take it slow course but I am now at risk of early death or transplant if I am lucky enough to get one and survive if I do get to the point of total failure or HCC.
Personally I think 56 is a little too young to die and if these new drugs can save my live I will be indescribably grateful to the scientists who found these new drugs.
Not being gullible to corporate advertising in the least.
About the newly diagnosed folks who have no liver disease are you suggesting they should walk around with a potentially live altering virus that has you thinking about the dangers of infecting your family and if single wondering if you are safe to even start a relationship? Also how would a person you would like to get to know romantically react to a person with the virus?
Why carry that load on your shoulders when you can be cured and put hep c behind you and go on with your life?
What wouild be an informed reason to not be treated especially as a very tolerable cure for most is at hand? Because we shouldn't be afraid of hep c because it takes a long time to harm us? Once you do have liver damage we are harder to cure even with these new medicines.
Personally for me I can see no reason to not be treated early so you never will have to deal with these issues.
Best of luck to all
Lynn
I have had hep c probable since 1977 and was diagnosed with cirrhosis in Jan 2008. So my odds of HCC are about 20% every year.
Basically ever since I was DX with cirrhosis I have had new symptoms come around every year it seems.
So yeah hep c has take it slow course but I am now at risk of early death or transplant if I am lucky enough to get one and survive if I do get to the point of total failure or HCC.
Personally I think 56 is a little too young to die and if these new drugs can save my live I will be indescribably grateful to the scientists who found these new drugs.
Not being gullible to corporate advertising in the least.
About the newly diagnosed folks who have no liver disease are you suggesting they should walk around with a potentially live altering virus that has you thinking about the dangers of infecting your family and if single wondering if you are safe to even start a relationship? Also how would a person you would like to get to know romantically react to a person with the virus?
Why carry that load on your shoulders when you can be cured and put hep c behind you and go on with your life?
What wouild be an informed reason to not be treated especially as a very tolerable cure for most is at hand? Because we shouldn't be afraid of hep c because it takes a long time to harm us? Once you do have liver damage we are harder to cure even with these new medicines.
Personally for me I can see no reason to not be treated early so you never will have to deal with these issues.
Best of luck to all
Lynn
Wow, I didn't mean to get that started, just to be clear, I was borderline cirrhotic, treated with incivek, inf and riba for 48 wks and would do it again in a heartbeat to beat this nasty virus
Fasting in people with liver disease (and just because the virus is gone does not mean the liver is healthy) can be dangerous. Please DO NOT fast without the guidance of your gastro or hepatologist. None of us here are doctors, including myself, but it is always prudent to be safe rather than sorry.
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