Aa
Summary of new treatments
http://www.medhelp.org/posts/Hepatitis-C/New-treatment-drugs-/show/1142402
I was looking for information on IC41, a treatment vaccine and ran across this post which gives a great summary of what's coming.
I'm also interested in Lamba replacing the current injections without the sx. It's the side effects and efficacy, what successful meds are all about.
I was looking for information on IC41, a treatment vaccine and ran across this post which gives a great summary of what's coming.
I'm also interested in Lamba replacing the current injections without the sx. It's the side effects and efficacy, what successful meds are all about.
Yes, it seems to have dropped off the pipeline of drugs. Made it all the way to stage 3.
Feeling better each day.
Judy
Feeling better each day.
Judy
“Now is there something to take the place of that awful riba?”
Yes, now that you mention it, there is.
Viramidine (taribavirin) was developed as a prodrug of ribavirin with much less red cell toxicity; it was in trial when I was treating in 2005. I recall my doctor was very excited about it at the time.
http://www.hivandhepatitis.com/2008icr/easl/docs/050908_a.html
"The data from this Phase IIb study demonstrated comparable efficacy between weight-based dosing of taribavirin and ribavirin," the investigators concluded. "Taribavirin at 20 and 25 mg/kg had a statistically lower anemia rate than ribavirin with overall similar tolerability."
They added that, "These results suggest that weight-based dosing of taribavirin at higher doses may be an alternative to ribavirin for the treatment of hepatitis C with an advantage for anemia."
If I recall, it didn’t receive FDA approval because it didn’t have *superior* efficacy over ribavirin, despite its better tox profile… go figure.
Bill
Yes, now that you mention it, there is.
Viramidine (taribavirin) was developed as a prodrug of ribavirin with much less red cell toxicity; it was in trial when I was treating in 2005. I recall my doctor was very excited about it at the time.
http://www.hivandhepatitis.com/2008icr/easl/docs/050908_a.html
"The data from this Phase IIb study demonstrated comparable efficacy between weight-based dosing of taribavirin and ribavirin," the investigators concluded. "Taribavirin at 20 and 25 mg/kg had a statistically lower anemia rate than ribavirin with overall similar tolerability."
They added that, "These results suggest that weight-based dosing of taribavirin at higher doses may be an alternative to ribavirin for the treatment of hepatitis C with an advantage for anemia."
If I recall, it didn’t receive FDA approval because it didn’t have *superior* efficacy over ribavirin, despite its better tox profile… go figure.
Bill
Zalbin is in the same spot as Teleprevir on the pipeline to market, so looks like next summer we may have 2 new tx options in the mix of 3. Thank you all for this great information. I am hoping for a smoother and more positive treatment coming soon to all. There is a lot of money to made treating HCV. The easier the tx, the more likelihood for success. There is a large population of homeless with hep c. I can't imagine doing today's SOC with what's currently prescribed. And many of the homeless have insurance or are eligible for it. Then there are patients around the world with HCV. Lots of money to be made, thank goodness, or else we would never get treatment.
Zalbin, I'll be tracking that one too. It should be coming close to the end of testing. A shot every 2wks would be better. Now is there something to take the place of that awful riba?
If there wasn't a financial incentive there would be no new medications, technology, inventions. Money is what drives it. It's why the communist economic system failed. Ours is not a perfect system. Think about this. A drug company finds a great new tx, spends lots of money but it's not a cure. Company #2 comes up with a cure. They get the jack pot of business. It's also about competition.
Unfortuantely for the sick, pharma is a business, and the sole objective of management is to make as much money as possible for the shareholders. The researchers, etc are more concerned with the good they are doing - but management gets paid to make money, period.
I've found over the years that if I ever really want to know what's happening in a system devised by man, all I have to do is "follow the money". Seriously.
Another unfortunate fact is that it's usually more profitable to treat, rather than cure. Does this play into decisions? One would hope not, but I wonder.
I've found over the years that if I ever really want to know what's happening in a system devised by man, all I have to do is "follow the money". Seriously.
Another unfortunate fact is that it's usually more profitable to treat, rather than cure. Does this play into decisions? One would hope not, but I wonder.
"It's the side effects
and efficacy, what successful meds
are all about"
You'd think so, wouldn't you.
That's why it's so hard to explain why something like Albuferon has sat on the shelf for 7+ years, when it's known that it's just as effective as the PEGs with fewer side effects. (I mean come on, it takes that long to develop a "dosing schedule"?)
At the same time, huge chunks of $$$ have been sunk into developing the PIs, which stand to make the manufacturers even more $$$$$.
Oh wait, maybe it's not so hard to explain.
Regardless, it's always great to see something of Mr Liver's reposted - a 'six star' poster and 'top top answerer'.
and efficacy, what successful meds
are all about"
You'd think so, wouldn't you.
That's why it's so hard to explain why something like Albuferon has sat on the shelf for 7+ years, when it's known that it's just as effective as the PEGs with fewer side effects. (I mean come on, it takes that long to develop a "dosing schedule"?)
At the same time, huge chunks of $$$ have been sunk into developing the PIs, which stand to make the manufacturers even more $$$$$.
Oh wait, maybe it's not so hard to explain.
Regardless, it's always great to see something of Mr Liver's reposted - a 'six star' poster and 'top top answerer'.
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