Aa
Telprevir Opportunity
I called my Hep. Doctor about telaprevir. Dr. Shen @ I.U Medical Center in Indianapolis. His assistant said there is a good possibilty that I can get into the trial. Is there anyone who has Dr. Shen as a doctor? I found out in April 2007 about my hep C.As some of you may know I decided to wait to treat.I don't know if I should wait for this drug to come out of trials so that I know so I know I won't get the placebo or just jump in. I don't have no liver damage so I know I have time to wait but I would really like to get this over with.What to do?
Very briefly,
1) Telaprevir has two big things going for it,higher SVR rate 66% vs 46%.(provisional figures).
2) It's real,it exists and it will be here soon.
3) Yes the Phase 1 monotherapy trials showed it suppressed viral reproduction for just a few days.Possibly only good for one shot.
4) No polymerase inhibitor in advanced trials.(I think-haven't checked)
5) Even if there were you couldn't just mix 'em up-extensive trials would be needed to approve a four way comb for efficacy and safety,let alone cost effectiveness!
6) For those who fail on Telaprevir it will be like anything else,new stratagies will be worked up same as with SOC
7) No prospect of interferon free treatment at this time-was just given by Jim as an example of where we may be in the future
1) Telaprevir has two big things going for it,higher SVR rate 66% vs 46%.(provisional figures).
2) It's real,it exists and it will be here soon.
3) Yes the Phase 1 monotherapy trials showed it suppressed viral reproduction for just a few days.Possibly only good for one shot.
4) No polymerase inhibitor in advanced trials.(I think-haven't checked)
5) Even if there were you couldn't just mix 'em up-extensive trials would be needed to approve a four way comb for efficacy and safety,let alone cost effectiveness!
6) For those who fail on Telaprevir it will be like anything else,new stratagies will be worked up same as with SOC
7) No prospect of interferon free treatment at this time-was just given by Jim as an example of where we may be in the future
I admit I am only an amateur when it comes to HCV, but my impression was that this forum is a discussion group for HCV patients and others interested in HCV.
What I meant in my previous post is that there are going to be some patients who do not receive SVR even with telaprevir, and for them it might have been a better option to have waited to treat with telaprevir and instead do a combo tx when available with for example both SOC, telaprevir and a polymerase inhibitor, or maybe even with the elusive interferon replacement Jim talks about. If these people had first done SOC only instead, they would have seen how they reacted to interferon and ribavirin and then maybe have decided to wait for additional drugs aside from telaprevir.
I do wonder what is going to happen to those who do not SVR with telaprevir. What if they are relapsers and just did not tx long enough? Will they then be offered 72 weeks of SOC as a second tx? Or will they go on to try SOC and a polymerase inhibitor or what? From what I have read there is a worry that people will go on to receive resistance to multiple HCV tx drugs in the future like what has happened to HIV patients.
Now if you excuse me, I want to see a movie on TV (I do have a life besides HCV), so I do not have time to make sure that there is nothing for you to object on in my unprofessional post. Maybe you should put together an exam for approval of those entering posts on the forum, as there seems to be only one opinion verified by facts according to you.
Jim, I now remember reading that "all stages (except stage 4) have an equal chance of SVR". But I still agree with Ala, why not treat sooner than later if you are going to end up treating anyway. I want my liver as healthy as possible.
What I meant in my previous post is that there are going to be some patients who do not receive SVR even with telaprevir, and for them it might have been a better option to have waited to treat with telaprevir and instead do a combo tx when available with for example both SOC, telaprevir and a polymerase inhibitor, or maybe even with the elusive interferon replacement Jim talks about. If these people had first done SOC only instead, they would have seen how they reacted to interferon and ribavirin and then maybe have decided to wait for additional drugs aside from telaprevir.
I do wonder what is going to happen to those who do not SVR with telaprevir. What if they are relapsers and just did not tx long enough? Will they then be offered 72 weeks of SOC as a second tx? Or will they go on to try SOC and a polymerase inhibitor or what? From what I have read there is a worry that people will go on to receive resistance to multiple HCV tx drugs in the future like what has happened to HIV patients.
Now if you excuse me, I want to see a movie on TV (I do have a life besides HCV), so I do not have time to make sure that there is nothing for you to object on in my unprofessional post. Maybe you should put together an exam for approval of those entering posts on the forum, as there seems to be only one opinion verified by facts according to you.
Jim, I now remember reading that "all stages (except stage 4) have an equal chance of SVR". But I still agree with Ala, why not treat sooner than later if you are going to end up treating anyway. I want my liver as healthy as possible.
'No brainer' means a decision that is easy to make.
It does not accusing someone of having no brain.
It is an English expression and is perhaps not used in the USA.
In any event you have read me wrong on the arrogance charge!
It does not accusing someone of having no brain.
It is an English expression and is perhaps not used in the USA.
In any event you have read me wrong on the arrogance charge!
First sentence should have read in part:
"I think you *Misread* he "Win-R" trial findings..."
"I think you *Misread* he "Win-R" trial findings..."
Milked: I read multiple times that a pre-fibrosis liver has a better chance of fighting the virus than one that is scarred.
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I think you read the "Win-R" trial findings, you mentioned in your last post. As i stated earlier, all stages (except stage 4) have an equal chance of SVR.
From Win-R Study:
"...In the entire population of patients logistic regression showed no statistically significant difference in SVR rates between Stage 0 (44%), Stage 1 (46%), Stage 2 (44%) and Stage 3 (44%)...
http://www.hivandhepatitis.com/2006icr/ddw/docs/052306_e.html
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Ala...In answer to your question, because the treatment itself arguably can do more damage than the potential for what you listed ESPECIALLY for someone with little or no damage and the relatively short (however you count it) timetable for Telaprevir to most probably reach market. Thanks btw for the nice words.
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HCA...Agree on all points
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Mike...I don't think that is what anyone said although I've been called worse for advocating "Watch and Wait" :)
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I think you read the "Win-R" trial findings, you mentioned in your last post. As i stated earlier, all stages (except stage 4) have an equal chance of SVR.
From Win-R Study:
"...In the entire population of patients logistic regression showed no statistically significant difference in SVR rates between Stage 0 (44%), Stage 1 (46%), Stage 2 (44%) and Stage 3 (44%)...
http://www.hivandhepatitis.com/2006icr/ddw/docs/052306_e.html
-------------------------
Ala...In answer to your question, because the treatment itself arguably can do more damage than the potential for what you listed ESPECIALLY for someone with little or no damage and the relatively short (however you count it) timetable for Telaprevir to most probably reach market. Thanks btw for the nice words.
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HCA...Agree on all points
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Mike...I don't think that is what anyone said although I've been called worse for advocating "Watch and Wait" :)
Less than 2 year for Telaprevir? Maybe, and it may not be available before 2011. I just saw that while researching the stock for investment reasons.
We really do not know whether there may be long term risks associated with PIs either. We haven't had enough time to examine that unless you want to look at HIV patients and extrapolate.
I am personally very hopeful regarding Telaprevir but I wouldn't call someone who chose to treat rather than to "watch and wait" a person without a brain.
I am continually dismayed at the arrogance I see here.
Mike
We really do not know whether there may be long term risks associated with PIs either. We haven't had enough time to examine that unless you want to look at HIV patients and extrapolate.
I am personally very hopeful regarding Telaprevir but I wouldn't call someone who chose to treat rather than to "watch and wait" a person without a brain.
I am continually dismayed at the arrogance I see here.
Mike
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