Didn't make it.

[hcvJames]

Oops. Looks like a relapse. Well can't say didn't know it was a possibility. Had SOC tx with Interferon and Riba. So odds were in the 40-45% range, minus some for age, 58 when started, weight, and cirrhosis. There is a copy of the results on my profile picture page under 11/21/11-VL. Also there are copies of the components making up a MELD score. Never had one done b4 now. The way I figure it, it's 6. Thanks to eureka and others it wasn't too heart stopping to see as it's <15 and thankfully towards the lower end.
In other news ... during tx I had two big problems, WBC and Platelets. WBC is 4.6, barely in range by .2. Platelets @ only 84. For some reason they didn't give the neutrophil numbers used to figure ANC or many others.
Anyway. Have an appointment W afternoon. I'm on indigent care and got to hope they can line up another round of tx.
It's been asked and answered b4 but besides being lazy I'm kinda bummed out to look it up. With triple drug tx what are the odds for one with cirrhosis?
Also who has tx'd with SOC drugs then later had to tx with the extra drug. Did the third increase sides?
Thanks everyone.

[eureka254]

"Treating again isn't a question, it's an answer."
-----------------
What a tremendous and positive attitude you have, James, in spite of such awful disappointment... I'm so sorry that this treatment didn't work for you, but hopefully your experience will make the next go-around easier by familiarity.  The good thing is that while you were undetected your liver got a nice break from viral activity, so all was not for naught.  I'm really glad that your cirrhosis is well-compensated and the MELD low... keep living liver-healthy and use this time to heal and build strength for the next go round... take care of yourself. ~eureka

[flcyclist]

Well put.  Your great attitude is inspiring.  Best of luck to you moving forward.

[hcvJames]

Thanks for the support everyone. Treating again isn't a question, it's an answer. Like the first time I'll get through it with the help of the forum. The worst part, by far, was dealing with the confusion, fear, anxiety, frustration, and anger of tx'ng. You have to accept some of that no matter what but the support, info, and knowing there are others, dealing/dealt with it, went a far way to calming me down. So it will be again

[gene53]

James,
I have treated twice before and relapsed like many people here at this forum.
I am going to triple tx with incivek starting soon.
I encourage you to give it a try with me and lets kick this stuff's ***.

What ever you choose Best of Luck

Gene

[nygirl7]

Aw James I am just so damned sorry.......I know you dont even want to think of retreating but at least now there are better odds than those of us who did SOC ever dreamed of having. That is something to remain positive for.

I am so sorry you are such a nice person you certainly did not deserve this but I have a good feeling that you will surely succeed in the future. Do NOT give up. I wont let you!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Deb

[Boobert]

Not much else to say but I am also very sorry. What ever you decide to do next wish you the best.

Bob

[fretboard]

Plenty sorry to hear this news.  Hopefully things will change for you in a good way.  Godspeed to you!!

[Advocate1955]

Thanks for the clarification flcyclist.  Talk to your dr. about the new meds hcvJames.  Your chances for SVR are high on triple therapy.
Advocate1955

[can-do-man]

Being geno 1b is fine, as a matter of fact they seemed to do better with the PI's.

Due to a somewhat lower genetic barrier to the emergence of resistance, patients infected with genotype 1a HCV tend to fare less well, as reflected by the SVR rates, which were approximately 7% lower in genotype 1a patients compared with 1b patients.

http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx

[flcyclist]

Both 1a & 1b

[Advocate1955]

Oh, James, I just looked at your profile.  You have Genotype 1b according to your profile.  Someone else can chime in here, but I seem to recall that the new meds (Inc. and Vic.) are only approved for Genotype 1a.  Is that right?
Advocate1955

[Advocate1955]

Sorry to hear of your relapse.  My husband is Genotype 1a, age 57, and has beginning Cirrhosis.  He was diagnosed in 2007 and did SOC for 12 weeks that year, but was a partial responder.  He did a 2nd therapy (daily Infergen injections + Riba) in 2010 and was again a partial responder.  He is currently on triple therapy with Incivek.  His VL at 4 weeks was 78.  He just finished Week 8.  Side effects have been more difficult than SOC (the Incivek rash and anal/rectal discomfort/bleeding), but so far easier than the 2nd treatment last year.  As a previous partial responder with Cirrhosis, it's my understanding that he has a 59% chance of SVR.  As willbb said above, your chances of obtaining SVR are higher since you achieved viral response and then relapsed later.  Go for it.  Now is the time.  How advanced is your Cirrhosis?
Advocate1955

[James10500]

Sorry to hear this, wishing you the best moving forward!

[brianmo]

Sorry.  Can't answer you question but I am doing Triple with victrilis (boc) it's not bad, just the anemia that makes it hard but I stay on top of it with weekly blood draw.  Good luck, I am rooting for you!

Mo

[belle19]

so sorry to read your news.  i pray that you can retreat with the new meds.  hang in there.  you can do it.  best wishes for the future.  keep us posted.  belle

[willbb]

Sorry to hear this James,however your chances for success are excellent  as a relapser,given how they fared in the trials for prev. relapsers for either Vic or Inci(.links.below).iregardless of cirrhosis

You will get it next time....
Will


n subjects with cirrhosis at baseline, sustained virologic response was higher in those who received treatment with the combination of VICTRELIS with PegIntron and REBETOL for 44 weeks after 4 weeks of lead-in therapy with PegIntron and REBETOL (17/22, 77%) compared to those who received RGT (6/17, 35%).

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm255413.htm



Twenty-three percent of INCIVEK-treated subjects had cirrhosis at baseline. SVR rates among cirrhotic subjects who received INCIVEK combination treatment were: 87% (48/55)  for prior relapsers,

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm256328.htm.

[Diane1186]

Sorry to hear your news.  Looks like can-do-man was able to retreat successfully.  Wishing you the best in further treating your HCV.

[orphanedhawk]

Sorry to hear this.
It just means you are still on the path to rid yourself of Hep C.
You can do it!!

[can-do-man]

Also as for the sides, the main thing was the anemia was alot worse, besides that eveything else were pretty much the same.

[can-do-man]

Sorry to read this, but don't give up. I also have cirrhosis and relapsed with just SOC. Treated with Victrelis (boceprevir) and now i am SVR. There are many of us here that did and become SVR with cirrhosis.

As for your platelets they are going to run low, i started with them in the 80's, got in the mid 20's during tx. Hang in there, these new PI's increase your odds greatly, though you will be looking at 48 weeks.....

Best,
cando

[flcyclist]

Also very sorry to hear this news.  I can't answer your questions, but there are several on the forum that previously treated with SOC that are re-treating with the new PI's, some with cirrhosis.  Hope you get some helpful advice.  

[pooh55811]

I am very sorry to hear that you have relapsed. I hope you can get treatment with the triple med regimen. I don't know the answer to your questions but I wanted to lend my support. I am sure some others will respond soon with answers for you.