EVR again.

[SNAP9]

Just learned that I EVR'd five weeks into Peg-Intron and Ribosphere TX.   Facts,  49 years old,  grade 3 fibrosis with bridging, stetios hepatitis , Grd 2 inflammation.   I did 24 week treatment last year , relapsed three weeks after completion,

I'm doing 9 months of TX this go around.,   I have genotype 3A.  

Will I cure?

[nygirl7]

I believe as a G3 relapser you do need to do the full 48 weeks.  G3 can be as difficult as a geno1 to deal with sometimes.  Since you've already treated 24 weeks why not go for the full routine with more meds and bash in the head for good?

Make sure you are getting really sensitive PCRs done - none  of this <315 stuff, <50 should be the tops so you are SURE of when you are undetectible.  Personally I'd ask for <2 myself.

Good luck.

[SNAP9]

thanks for answers

[epiphiny]

I also think you have a very good chance of clearing but as you are a relapser I think you need to treat for the full 48 weeks.  I don't understand why you have been told to treat for 9 months.

I also was a G3a; I was a null responder to 24 weeks of SOC and I treated again in May last years.  I was lucky enough to get on a polymerase inhibitor trial which also gave me a UND result at 4 weeks however, based on my previous lack of response, I really pushed to treat for a full 48 weeks.  It was hard but it was worth it as I also reached SVR!

As Marcia has mentioned it is essential you get the right amount of Riba for your weight, especially at the beginning of your treatment. Unfortunately, there are still docs out there that just prescribe the standard 800mgs per day for a Geno 3, despite the weight of the individual patient.  I have often wondered whether my lack of response first time round was due to not enough Riba rather than a particularily resitant form of the virus.  My dose first time round was 800mgs and my 2nd time round it was upped to 1200mgs per day.

The weight based protocols are 13 - 15mgs of Riba per kg of weight so you can easily work out the right dosage for your weight.  If you are not on weight-based I would question your Doctor, and consider moving to another Doc.  Preferably a Hepatologist, rather than a GP.  Hopefully, you are on weight based though.

This board is great for information and inspiration and I would strongly recommend you check in here often.  I attribute my SVR in part to all the great advice and support I found here.  There are a lot of things you can do for yourself to enhance the treatment process and raise your chances of success.

Epi.

[Marcia2202]

Personally I think that you should be able to beat it this time with prolonged tx and EVR at 5 weeks.

I'm a fellow 3a'er, or lets say I was, as I attained SVR this month.

I still had 80 VL at 4 weeks and coerced my doctors to prolong treatment. I ended up treating 8 months.

Since you have more damage than me (F0-1 after completing tx, could not have a biopsy prior to tx) it looks like you are on the right track.

Are you on weight based riba?