Alt AST GGT hight HCV RNA Not detectable.

[shnawer]

Hi

I completed my 6 month Interferone and ribavirne in 2008. I have genotype 3b. I have done LFT two times and they all were fine. Yesterday (5/8/2013) the report of HCV RNA qualitative is "Not Detectable" but LFT is high is suger level.

Glucosio : 114 >           65-99
AST : 45 >                      5-34
ALT :  88 >                      0-55
GGT : 89 >                     12-64
ALP :  93                           40 - 150

Bilirubina Totale 0.7 mg/dL 0.2 - 1.2
Bilirubina Diretta 0.2 mg/dL < 0.5
Bilirubina Indiretta 0.5 mg/dL 0.1 - 0.7

Anti HCV  = POSTIVE

HCV-RNA (Method PCR real-time) : Not Detectable


What is went wrong? I have appointment with dr. after one week what I should ask him to write me?

Please help

Thanks

[shnawer]

No. I don't drink Alcohol, never in my live . No smoking also I quit 10 years back. I have done LFT in 2011 and 2010 they both were fine. I am not under any medication.

Note: from last 6 months I am drinking "Carbonated water" may it is the cause? . I work hard but not very very hard. But I walk almost 7 hours in 8 hours of work. But I am doing this work from last 10 years and my LFT was even fine then.

[dontworry_behappy1]

Sorry you are having health issues and going to the doctor next week.  The people on this forum aren't doctors and have no way of knowing what is wrong with you.  Something has changed with your LFT and Sugar levels are high.  What is wrong with you is something you ask your doctor at your appointment next week.  You don't have Hepatitis C.

Best To You

[hrsepwrguy]

"Every PCR I've gotten only went to <49"

I think it's <43 Not Detected ( I haven't ever seen a <49 but I could be wrong) and that actually means that you are not detectable down to 7.1 or 10 IU/ml depending on genotype

Question 2. What do these test results mean: “<43 Detected” or “<43 Not Detected”?

According to the reagent manufacturer, the lower limit of detection differs from the limit of quantification. The lowest viral load this assay can accurately quantify is 43 IU/mL, but the limit of detection is 7.1 IU/mL for genotype 1 viruses, and 10 IU/mL for viruses with all other genotypes. Therefore, we can qualitatively report detection even if the viral load is under 43 IU/mL (ie, <43 Detected). Thus, “7.1 or >10 IU/mL, but <43 IU/mL). A “<43 Not Detected” means the assay did not detect HCV RNA (ie, RNA <7.1 or <10 IU/mL). This is compliant with the package insert guidelines for the new direct-acting antivirals boceprevir and telaprevir.

If a quantitation below 43 IU/mL is desired, please order the Heptimax®HCV RNA test. This test provides our broadest analytical measurement range. By combining real-time PCR and transcription mediated amplification (TMA) technology into a progressive test, we can report a viral load range between 5 and 69,000,000 IU/mL. This is the most sensitive HCV RNA test available.

http://education.questdiagnostics.com/faq/HCV-RNA-PCR

[willbb]

No one but your doctor would be able to ascertain why your levels above are slightly elevated hower given the lab report that states :


HCV-RNA (Method PCR real-time) : Not Detectable


You do not have HCV regardless of the sensitivity of the test.

Will

[can-do-man]

Not really sure what your point is, if one wants to pay extra so be it. In the OP's case after 5 years his viral load is Not Detectable so paying for a more sensitive test is not only a waste of his time but his money.

You are all of a sudden are all over this forum, and frankly you make no sense. And yes if one relapses they would have a higher viral load then below 10. So after 5 years it is quite clear Hep C is not his problem

[medic54]

Every PCR I've gotten only went to <49, my TMA's to <10. Granted, some may be more exact (I've read of a PCR technique that measures to <25).
OCI measurements are detected with NAAA at between 0.5 and 2.5 IU and even then often 'undetectable'...though by testing other days/times and other samples (plasma, lymph) it is eventually found, the values are very low and fluctuate... hence some studies have base OCI's non-existence off one lab draw... and call it science.
"..after many years it would be higher"? Random variation suggests that because it happened 99 times does not necessarily mean in will happen 100.

[can-do-man]

Not sure what is wrong but with this statement...

"HCV-RNA (Method PCR real-time) : Not Detectable"

You do not have a viral load, after that many years it would be higher then 10......... Good luck

[medic54]

ALT/AST- alcohol use? heavy exercise? Glucose- meal within 12 hrs?
All of the above are some commonly associated influences with the minor elevations on your labs. But with a history of HCV with those labs, I would ask my doc to write for a TMA RNA (<10 IU.... most PCR are only sensitive to <49 IU), and though TMA is far from absolute, it's the best commercially available.