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pathology report question...
I was trying to add to my other question...but it wouldn't let me, so I am very SORRY to start another thread...
What are the chances that the HCC can come back post transplant, either in the new liver or as a metasized cancer elsewhere in the body???
Here is Pathology:
1. The trichrome stain confirms absence of fibrosis. there is no macrovesicular steatosis or necrosis.
2. The specimen reveals a 1.2cm partially necrotic subcapsular nodule in right lobe. The necrotic nodule demonstrates residual moderately differentitated hepatocellular carcinoma.
Tumor size 1.2cm,
Solitary tumor in right lobe
Tumor Necrosis: present 80%
Tumor extension:Tumor confined to liver
Hilar margin: hilar margin is uninvolved by carcinoma
Distance of invasive carcinoma from closest margin: 5cm,
Primary tumor
pT1: solitary tumor without vascular invasion
Fibrosis score: 4
Based on this pathology report...Is there a chance HCC will come back either in new liver or as a mestastic cancer?
What are the chances that the HCC can come back post transplant, either in the new liver or as a metasized cancer elsewhere in the body???
Here is Pathology:
1. The trichrome stain confirms absence of fibrosis. there is no macrovesicular steatosis or necrosis.
2. The specimen reveals a 1.2cm partially necrotic subcapsular nodule in right lobe. The necrotic nodule demonstrates residual moderately differentitated hepatocellular carcinoma.
Tumor size 1.2cm,
Solitary tumor in right lobe
Tumor Necrosis: present 80%
Tumor extension:Tumor confined to liver
Hilar margin: hilar margin is uninvolved by carcinoma
Distance of invasive carcinoma from closest margin: 5cm,
Primary tumor
pT1: solitary tumor without vascular invasion
Fibrosis score: 4
Based on this pathology report...Is there a chance HCC will come back either in new liver or as a mestastic cancer?
MEDICAL PROFESSIONAL
The PIVKA is not used by many transplant centers--I am sorry that i dont know a lot about it. The DCP is also not routinely used. The histopathology is by far the most important and predictive factor for recurrence. I really wouldnt worry about the slightly elevated PIVKA level whatsoever
Thank you, Dr, Schiano.
What type of blood test is the "des-γ-carboxy prothrombin (DCP)"? Is this the same test as the "PIVKA II" test? Is the DCP test used as a tumor marker test?
The reason I keep asking about the PIVKA II test is...prior to transplant as well as up to 9 months post transplant, PIVKA II tests results were ALWAYS <2.0 (normal range is <6.3 ng/mL). During the 9 month post transplant visit the level was 3.8. Although this is within the "normal range", it is elevated from prior results. I worry and stress that it is indicative of HCC recurrence. How reliable is this Pivka test? Can these types of tests fluctuate?? Extremely confused as to why some transplant facilities use the PIVKA II test and others do not? I would greatly appreciate any advice. Thank you.
What type of blood test is the "des-γ-carboxy prothrombin (DCP)"? Is this the same test as the "PIVKA II" test? Is the DCP test used as a tumor marker test?
The reason I keep asking about the PIVKA II test is...prior to transplant as well as up to 9 months post transplant, PIVKA II tests results were ALWAYS <2.0 (normal range is <6.3 ng/mL). During the 9 month post transplant visit the level was 3.8. Although this is within the "normal range", it is elevated from prior results. I worry and stress that it is indicative of HCC recurrence. How reliable is this Pivka test? Can these types of tests fluctuate?? Extremely confused as to why some transplant facilities use the PIVKA II test and others do not? I would greatly appreciate any advice. Thank you.
MEDICAL PROFESSIONAL
this is correct. Again, remember that your risk of recurrence is exceedingly, exceedingly low
Hi Dr. Schaino.
I am sorry, I am a little confused. Can you please explain for me…
If AFP was NOT elevated prior to transplant (for someone who had HCC), then the AFP test would NOT be a reliabl/sensitive test, post transplant, for someone who possibly may have recurrent HCC?
So beside CT or MRI and the tumor maker tests of AFP & AFPL3%, there are no additional tests to check for HCC?
Thank you = )
I am sorry, I am a little confused. Can you please explain for me…
If AFP was NOT elevated prior to transplant (for someone who had HCC), then the AFP test would NOT be a reliabl/sensitive test, post transplant, for someone who possibly may have recurrent HCC?
So beside CT or MRI and the tumor maker tests of AFP & AFPL3%, there are no additional tests to check for HCC?
Thank you = )
MEDICAL PROFESSIONAL
correct AFP would be reliable post if not elevated pre. Really there are no other tests to assess
Thank you.
If AFP wasn't elevated prior to transplant, then would the AFP be a reliable test post transplant?
In addition to the the scans (CT or Mri) and the AFP, are there any other tests that should be done to monitor for recurrent HCC?
If AFP wasn't elevated prior to transplant, then would the AFP be a reliable test post transplant?
In addition to the the scans (CT or Mri) and the AFP, are there any other tests that should be done to monitor for recurrent HCC?
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