Cisplatin Side Effects

[westgal]

After optimal debulking surgery in April 2006 at age 53 that included complete hysterectomy, removal of both ovaries, omentum, and spleen and diagnosis of stage 3c epithelial (serous) ovca, I had 2 rounds of intraperitoneal chemo (Cisplatin/Taxol) before this regimen was discontinued due to side effects related to renal function (Creatinine rose from 2.1 to 3.1 over the course of the 2 rounds despite aggressive in-patient hydration).

After my Creatinine level decreased and stabilized, I then completed 4 rounds of IV Carboplatin/Taxol (with no further renal problems) in October, 2006.

The good news is that so far I have had no evidence of disease since. Yet, even though I keep my protein intake to 40-50 grams/day, stay hydrated, avoid caffeine, etc., my Creatinine level averages 2.5 which effects my red cell count. The fatigue has been on-going and had a red-cell booster shot which helped somewhat.

My med onc tells me that all I need to do is drink 64 oz of my favorite non-alcoholic beverage(s) every day. This doesn't seem to be doing it for me. I'd greatly appreciate any suggestions of what else could be helpful.  

[westgal]

Thank you for your ideas. A nephrologist saw me after the 2nd round of Cisplatin when I had a kidney ultrasound (it was normal, thank God). Evidently I have to be careful not to ingest anything that disturbs the kidneys even though this is a only a mild impairment from the chemo. It may be reversable over time and I want to do everything I can to help it along. I will look into whether the B12 can help when have an appt next week for check-up on how kidney function is now. I have been very happy with how things have gone so far, and just pray the ovca stays in remission. Thanks again.  

[freshair]

Wow, that peritoneal IV is difficult. Yes, tons of water helps those kidneys.

Have you tried sublingual B12. It really helped me. A deficiency causes anemia. Also see a nutritional counselor specially on your kidney trouble. I had one at the hospital that recommended B vitamins, green tea, mushrooms and other stuff. A lot of time you can get the injections at the hospital. I did not have the peritoneal treatment and maybe you'll get a post from someone that has had it. With all the studies out there, your treatment that you had shows a better response but I am sorry you have run into this. Yes, see a kidney doctor. Why not. Best of luck to you.

[rmarie]

Have you been referred to a nephrologist for a consultation regarding your kidney functioning?  This is a physician that specializes in the treatment of problems with kidneys, if you haven't had one, ask for it, you deserver to know exactly what is going on.  Good luck