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Long Term effects of pain med
I am seeking help with problems no doctor can find diagnosis. I've taken Oxycontin for 7 years now, and need to know what effects others have had from long term use?
I find it funny that everybody is concerned with the long term use and not how do i get off the drug also the constipation is something i never had from taking narcotic medication if you eat a proper diet you wont. As to the Tramadol raising BP many medications can do that you are puuting checmicals in your body which was not designed to proccess the things you stick it in ways you would like so you have to just relax and let your body adjust and things willl be ok
Thank you for your comments re loss of bone density. It helps to know that she (my friend) is likely just getting old (like the rest of us!) and her osteo is likely not caused by her meds.
JVLB123
JVLB123
HYPERALGESIA my doctor has actually talked to me about a condition called hyperalgesia where the cns is actually over excited by the opiates instead of depressed and causes more pain where you need more opiates. he described is as"an endless circle" of needing more and more of the opiates. this is one of the reasons he wants me to seriously consider the pain pump, less medication and obviously more powerful going right into the spine but you also don't have the internal organ problems cuz you are using less medication.
So interesting about the sugar comments huh! me too love that sugar along with the oxycontin.
So interesting about the sugar comments huh! me too love that sugar along with the oxycontin.
This is an article from JAMA,
About loss of bone density while on opioids and other drugs. There are many studies about this you can search from an educational search engine and find quite a few. A scholar search engine will work as well.
Decreased bone mineral density defines osteoporosis according to the World Health Organization and is an important predictor of future fractures. The use of several types of central nervous system-active drugs, including benzodiazepines, anticonvulsants, antidepressants, and opioids, have all been associated with increased risk of fracture. However, it is unclear whether such an increase in risk is related to an effect of bone mineral density or to other factors, such as increased risk of falls. We sought to examine the relationship between bone mineral density and the use of benzodiazepines, anticonvulsants, antidepressants, and opioids in a representative US population-based sample.
Subjects and methods
We analyzed data on adults aged 17 years and older from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). Total femoral bone mineral density of 7114 male and 7532 female participants was measured by dual-energy x-ray absorptiometry. Multivariable linear regression models were used to quantify the relation between central nervous system medication exposure and total femoral bone mineral density. Models controlled for relevant covariates, including age, sex, and body mass index.
Results
In linear regression models, significantly reduced bone mineral density was found in subjects taking anticonvulsants (0.92 g/cm2; 95% confidence interval [CI]: 0.89 to 0.94) and opioids (0.92 g/cm2; 95% CI: 0.88 to 0.95) compared with nonusers (0.95 g/cm2; 95% CI: 0.95 to 0.95) after adjusting for several potential confounders. The other central nervous system-active drugs—benzodiazepines or antidepressants—were not associated with significantly reduced bone mineral density.
Conclusion
In cross-sectional analysis of NHANES III, anticonvulsants and opioids (but not benzodiazepines or antidepressants) were associated with significantly reduced bone mineral density. These findings have implications for fracture-prevention strategies.
About loss of bone density while on opioids and other drugs. There are many studies about this you can search from an educational search engine and find quite a few. A scholar search engine will work as well.
Decreased bone mineral density defines osteoporosis according to the World Health Organization and is an important predictor of future fractures. The use of several types of central nervous system-active drugs, including benzodiazepines, anticonvulsants, antidepressants, and opioids, have all been associated with increased risk of fracture. However, it is unclear whether such an increase in risk is related to an effect of bone mineral density or to other factors, such as increased risk of falls. We sought to examine the relationship between bone mineral density and the use of benzodiazepines, anticonvulsants, antidepressants, and opioids in a representative US population-based sample.
Subjects and methods
We analyzed data on adults aged 17 years and older from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994). Total femoral bone mineral density of 7114 male and 7532 female participants was measured by dual-energy x-ray absorptiometry. Multivariable linear regression models were used to quantify the relation between central nervous system medication exposure and total femoral bone mineral density. Models controlled for relevant covariates, including age, sex, and body mass index.
Results
In linear regression models, significantly reduced bone mineral density was found in subjects taking anticonvulsants (0.92 g/cm2; 95% confidence interval [CI]: 0.89 to 0.94) and opioids (0.92 g/cm2; 95% CI: 0.88 to 0.95) compared with nonusers (0.95 g/cm2; 95% CI: 0.95 to 0.95) after adjusting for several potential confounders. The other central nervous system-active drugs—benzodiazepines or antidepressants—were not associated with significantly reduced bone mineral density.
Conclusion
In cross-sectional analysis of NHANES III, anticonvulsants and opioids (but not benzodiazepines or antidepressants) were associated with significantly reduced bone mineral density. These findings have implications for fracture-prevention strategies.
Although I realize that it is probably impossible to eliminate sugar from your diet entirely, I can help you limit your intake. Here are some tips:
• Banish packaged products -- including those made with white flour -- and stick to food in its original form. Instead of canned fruit or juice, eat a piece of whole fruit.
• Drink plenty of water throughout the day; you may be mistaking dehydration for hunger.
• Eat protein at every meal; it is digested more slowly than simple carbohydrates and will leave you feeling fuller for a longer period of time. You will therefore be more likely to resist the urge to eat dessert every night after dinner.
• Give up your favorite sweet food for three weeks. It is likely that after three weeks, your tastes will have changed and your craving for sweets will not be as strong.
• Resist impulse snacking. If you crave a donut, take 15 minutes to think about it or go for a walk instead. Chances are, that after this delay period, your craving will have subsided.
Sugar effects serotonin and dopamine Sugar is the a natural narcotic it acts like a narcotic pill only it is natural. Some say that the natural good feeling you get from either triggers the brain wanting more and more sugar. I have read many articles that seem to think this is this case now I have no idea of knowing for sure.
I do know it is natural human behavior to keep craving something that makes us feel good so in my opinion the meds just jump start the sugar cravings and then your brain just wants more. Now again that is just my opinion.
Simply put, sugar triggers the production of the brain’s natural opioid (a substance that has a morphine-like effect on the body, though not as strong as morphine or heroin), as a result of this, the body (or more specifically the brain) starts to get addicted to its own opioid.
• Banish packaged products -- including those made with white flour -- and stick to food in its original form. Instead of canned fruit or juice, eat a piece of whole fruit.
• Drink plenty of water throughout the day; you may be mistaking dehydration for hunger.
• Eat protein at every meal; it is digested more slowly than simple carbohydrates and will leave you feeling fuller for a longer period of time. You will therefore be more likely to resist the urge to eat dessert every night after dinner.
• Give up your favorite sweet food for three weeks. It is likely that after three weeks, your tastes will have changed and your craving for sweets will not be as strong.
• Resist impulse snacking. If you crave a donut, take 15 minutes to think about it or go for a walk instead. Chances are, that after this delay period, your craving will have subsided.
Sugar effects serotonin and dopamine Sugar is the a natural narcotic it acts like a narcotic pill only it is natural. Some say that the natural good feeling you get from either triggers the brain wanting more and more sugar. I have read many articles that seem to think this is this case now I have no idea of knowing for sure.
I do know it is natural human behavior to keep craving something that makes us feel good so in my opinion the meds just jump start the sugar cravings and then your brain just wants more. Now again that is just my opinion.
Simply put, sugar triggers the production of the brain’s natural opioid (a substance that has a morphine-like effect on the body, though not as strong as morphine or heroin), as a result of this, the body (or more specifically the brain) starts to get addicted to its own opioid.
Actually Ive heard of this also
I am not exactly sure how it works because there is so little research on it at this point.
As far I as I understand, as time passes your body stores something the opioids release into your system. As time goes on more and more of it gets stored and begins to cause pain.
Also As someone takes a higher and higher dose your body can actually start producing pain to tell you it wants more. It learns more pain equals more opioids. Thats why alot of DR's wont raise a dose at a certain point.
About a year ago I had complained of pain and my DR told me that pain meds can actually cause your body more pain.
I've tried to look it up but found only one or two articles and i havent been able to find them since.
So the above is only my understanding of what my DR said and what I read.
TMA
I am not exactly sure how it works because there is so little research on it at this point.
As far I as I understand, as time passes your body stores something the opioids release into your system. As time goes on more and more of it gets stored and begins to cause pain.
Also As someone takes a higher and higher dose your body can actually start producing pain to tell you it wants more. It learns more pain equals more opioids. Thats why alot of DR's wont raise a dose at a certain point.
About a year ago I had complained of pain and my DR told me that pain meds can actually cause your body more pain.
I've tried to look it up but found only one or two articles and i havent been able to find them since.
So the above is only my understanding of what my DR said and what I read.
TMA
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