Well, I had my OB appt last week, and of course, she didn't want to steer me in any direction, because everything is my choice. It is, but I need advice! My downs first tri screen results were fine - my trisomy 13/18 were on the LOW end of fine. She said "if I were over 35, you'd be damn sure I'd have an amnio". And she said "if you had a 1 in 364 chance of being shot here at my office (my risk assessment for trisomy 13/18), you'd go over to St. Joseph's" (the hospital next to our hospital where her office is). She's essentially telling me to have an amnio to be sure. She then said "I've never missed a trisomy 13 or 18 on a level 2 ultrasound". So, I think I'm going with that. She's the best perinatologist/OB in town, and so many high riskers go to her, because she is the best. She also doesn't like to beat around the bush, so going to her is a little like going to House - you don't get much love, but you get tremendous care. So, I opted for the Modified Sequential Blood Screen, which is a newer blood test to combine with the first trimester results to get a perhaps clearer picture of the risks for downs and trisomy 13/18. The catch: slightly increased false positives with that test (particularly with Downs), and more accurate risk assessments though (a total contradiction). Then in two weeks, I have my level 2 u/s. Do I just skip this bloodtest and go straight for the level 2, knowing I really DO NOT want an amnio, and this bloodtest could just freak me out more? I am just an anxious mess. I need this baby to be healthy. My mom has been in and out of the hospital since memorial day, essentially losing a battle with life (hopefully not), and I have only begun to feel physically better at 16wks from the pregnancy. I'm just so emotionally drained and need some terrific news. Any of your thoughts are much appreciated. Thank you.